Multivariate Optimization of Electrochemical Biosensors for the Determination of Compounds Related to Food Safety-A Review

Overview

Journal Biosensors (Basel)

Specialty Biotechnology

Date 2023 Jul 28

PMID 37504093

Authors

Hector Fernandez

Maria Alicia Zon

Sabrina Antonella Maccio

Ruben Dario Alaniz

Aylen Di Tocco

Roodney Alberto Carrillo Palomino

Jose Alberto Cabas Rodriguez

Adrian Marcelo Granero

Fernando J Arevalo

Sebastian Noel Robledo

Gaston Dario Pierini

Affiliations

Soon will be listed here.

Abstract

We summarize the application of multivariate optimization for the construction of electrochemical biosensors. The introduction provides an overview of electrochemical biosensing, which is classified into catalytic-based and affinity-based biosensors, and discusses the most recent published works in each category. We then explore the relevance of electrochemical biosensors for food safety analysis, taking into account analytes of different natures. Then, we describe the chemometrics tools used in the construction of electrochemical sensors/biosensors and provide examples from the literature. Finally, we carefully discuss the construction of electrochemical biosensors based on design of experiments, including the advantages, disadvantages, and future perspectives of using multivariate optimization in this field. The discussion section offers a comprehensive analysis of these topics.

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