Protection Against Cadmium Toxicity by Zinc: Decrease in the Cd-high Molecular Weight Protein Fraction in Rat Liver and Kidney on Zn Pretreatment

The amounts of cadmium, associated with high molecular weight proteins, metallothionein and low molecular weight fractions obtained on Sephadex G-75 gel filtration, were determined in the liver and kidneys of rats treated with Cd. When rats were pretreated with zinc 24 h prior to the Cd injection, Cd associated with the high molecular weight proteins was decreased in both the liver and kidneys. Although the Cd concentration in the liver was increased, the liver showed less morphological damage in Zn-pretreated rats. The above results suggest that Cd-toxicity toward the liver and kidneys may be related to the accumulation of Cd in the high molecular weight proteins.