Travelling Under Pressure - Hypoxia and Shear Stress in the Metastatic Journey

Overview

Journal Clin Exp Metastasis

Specialty Oncology

Date 2023 Jul 25

PMID 37490147

Authors

Ece Su Ildiz

Ana Gvozdenovic

Werner J Kovacs

Nicola Aceto

Affiliations

Soon will be listed here.

Abstract

Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating tumor cells (CTCs) represent a highly selected subpopulation of cancer cells that tamed these critical steps, and a better understanding of their biology and driving molecular principles may facilitate the development of novel tools to prevent metastasis. Here, we describe key research advances in this field, aiming at describing early metastasis-related processes such as collective invasion, shedding, and survival of CTCs in the bloodstream, paying particular attention to microenvironmental factors like hypoxia and mechanical stress, considered as important influencers of the metastatic journey.

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