Nanoformulations of Quercetin for Controlled Delivery: a Review of Preclinical Anticancer Studies

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 2023 Jul 25

PMID 37490121

Authors

Hemant Joshi

Dhruv Sanjay Gupta

Ginpreet Kaur

Tejveer Singh

Seema Ramniwas

Katrin Sak

Diwakar Aggarwal

Raunak Singh Chhabra

Madhu Gupta

Adesh K Saini

Hardeep Singh Tuli

Affiliations

Soon will be listed here.

Abstract

One of the well-studied older molecules, quercetin, is found in large quantities in many fruits and vegetables. Natural anti-oxidant quercetin has demonstrated numerous pharmacological properties in preclinical and clinical research, including anti-inflammatory and anti-cancer effects. Due to its ability to control cell signaling pathways, including NF-κB, p53, activated protein-1 (AP-1), STAT3, and epidermal growth response-1 (Egr-1), which is essential in the initiation and proliferation of cancer, it has gained a lot of fame as an anticancer molecule. Recent research suggests that using nanoformulations can help quercetin to overcome its hydrophobicity while also enhancing its stability and cellular bioavailability both in vitro and in vivo. The main aim of this review is to focus on the comprehensive insights of several nanoformulations, including liposomes, nano gels, micelles, solid lipid nanoparticles (SLN), polymer nanoparticles, gold nanoparticles, and cyclodextrin complexes, to transport quercetin for application in cancer.

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