Carbon Dots: Opportunities and Challenges in Cancer Therapy

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Mar 29

PMID 36986879

Authors

Tanima Bhattacharya

Gye Hwa Shin

Jun Tae Kim

Affiliations

Soon will be listed here.

Abstract

Recently, carbon dots (CDs) have been actively studied and reported for their various properties. In particular, the specific characteristics of carbon dots have been considered as a possible technique for cancer diagnosis and therapy. This is also a cutting-edge technology that offers fresh ideas for treating various disorders. Though carbon dots are still in their infancy and have not yet shown their value to society, their discovery has already resulted in some noteworthy advancements. The application of CDs indicates conversion in natural imaging. Photography using CDs has demonstrated extraordinary appropriateness in bio-imaging, the discovery of novel drugs, the delivery of targeted genes, bio-sensing, photodynamic therapy, and diagnosis. This review seeks to provide a comprehensive understanding of CDs, including their benefits, characteristics, applications, and mode of action. In this overview, many CD design strategies will be highlighted. In addition, we will discuss numerous studies on cytotoxic testing to demonstrate the safety of CDs. The current study will address the production method, mechanism, ongoing research, and application of CDs in cancer diagnosis and therapy.

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References

Vedhanayagam M, Raja I, Molkenova A, Atabaev T, Sreeram K, Han D . Carbon Dots-Mediated Fluorescent Scaffolds: Recent Trends in Image-Guided Tissue Engineering Applications. Int J Mol Sci. 2021; 22(10). PMC: 8190637. DOI: 10.3390/ijms22105378. View

Bao X, Yuan Y, Chen J, Zhang B, Li D, Zhou D . In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration. Light Sci Appl. 2018; 7:91. PMC: 6249234. DOI: 10.1038/s41377-018-0090-1. View

Zhen Z, Tang W, Guo C, Chen H, Lin X, Liu G . Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer. ACS Nano. 2013; 7(8):6988-96. PMC: 3819164. DOI: 10.1021/nn402199g. View

Smith A, Duan H, Mohs A, Nie S . Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev. 2008; 60(11):1226-1240. PMC: 2649798. DOI: 10.1016/j.addr.2008.03.015. View

Gao X, Guo L, Li J, Thu H, Hussain Z . Nanomedicines guided nanoimaging probes and nanotherapeutics for early detection of lung cancer and abolishing pulmonary metastasis: Critical appraisal of newer developments and challenges to clinical transition. J Control Release. 2018; 292:29-57. DOI: 10.1016/j.jconrel.2018.10.024. View

Wu L, Wang J, Ren J, Li W, Qu X . Highly sensitive electrochemiluminescent cytosensing using carbon nanodot@Ag hybrid material and graphene for dual signal amplification. Chem Commun (Camb). 2013; 49(50):5675-7. DOI: 10.1039/c3cc42637h. View

Wen Y, Jia Q, Nan F, Zheng X, Liu W, Wu J . Pheophytin Derived Near-Infrared-Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy. Chem Asian J. 2019; 14(12):2162-2168. DOI: 10.1002/asia.201900416. View

Liu J, Li R, Yang B . Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications. ACS Cent Sci. 2020; 6(12):2179-2195. PMC: 7760469. DOI: 10.1021/acscentsci.0c01306. View

Zhang L, Lin Z, Yu Y, Jiang B, Shen X . Multifunctional hyaluronic acid-derived carbon dots for self-targeted imaging-guided photodynamic therapy. J Mater Chem B. 2020; 6(41):6534-6543. DOI: 10.1039/c8tb01957f. View

10.

Li S, Su W, Wu H, Yuan T, Yuan C, Liu J . Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids. Nat Biomed Eng. 2020; 4(7):704-716. PMC: 7197249. DOI: 10.1038/s41551-020-0540-y. View

11.

Varisco M, Zufferey D, Ruggi A, Zhang Y, Erni R, Mamula O . Synthesis of hydrophilic and hydrophobic carbon quantum dots from waste of wine fermentation. R Soc Open Sci. 2018; 4(12):170900. PMC: 5749999. DOI: 10.1098/rsos.170900. View

12.

Malavika J, Shobana C, Sundarraj S, Ganeshbabu M, Kumar P, Kalai Selvan R . Green synthesis of multifunctional carbon quantum dots: An approach in cancer theranostics. Biomater Adv. 2022; 136:212756. DOI: 10.1016/j.bioadv.2022.212756. View

13.

Zheng X, Ananthanarayanan A, Luo K, Chen P . Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications. Small. 2014; 11(14):1620-36. DOI: 10.1002/smll.201402648. View

14.

Zhang Y, Shen Y, Teng X, Yan M, Bi H, Morais P . Mitochondria-targeting nanoplatform with fluorescent carbon dots for long time imaging and magnetic field-enhanced cellular uptake. ACS Appl Mater Interfaces. 2015; 7(19):10201-12. DOI: 10.1021/acsami.5b00405. View

15.

Wang X, He K, Hu Y, Tang M . A review of pulmonary toxicity of different types of quantum dots in environmental and biological systems. Chem Biol Interact. 2022; 368:110247. DOI: 10.1016/j.cbi.2022.110247. View

16.

Subhan M, Yalamarty S, Filipczak N, Parveen F, Torchilin V . Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment. J Pers Med. 2021; 11(6). PMC: 8234032. DOI: 10.3390/jpm11060571. View

17.

Wang X, Sun X, Lao J, He H, Cheng T, Wang M . Multifunctional graphene quantum dots for simultaneous targeted cellular imaging and drug delivery. Colloids Surf B Biointerfaces. 2014; 122:638-644. DOI: 10.1016/j.colsurfb.2014.07.043. View

18.

Jia X, Han Y, Pei M, Zhao X, Tian K, Zhou T . Multi-functionalized hyaluronic acid nanogels crosslinked with carbon dots as dual receptor-mediated targeting tumor theranostics. Carbohydr Polym. 2016; 152:391-397. DOI: 10.1016/j.carbpol.2016.06.109. View

19.

Ren G, Jiang M, Xue P, Wang J, Wang Y, Chen B . A unique highly hydrophobic anticancer prodrug self-assembled nanomedicine for cancer therapy. Nanomedicine. 2016; 12(8):2273-2282. DOI: 10.1016/j.nano.2016.06.012. View

20.

Li L, Shi L, Jia J, Eltayeb O, Lu W, Tang Y . Dual Photoluminescence Emission Carbon Dots for Ratiometric Fluorescent GSH Sensing and Cancer Cell Recognition. ACS Appl Mater Interfaces. 2020; 12(16):18250-18257. DOI: 10.1021/acsami.0c00283. View