A Concise Review on the Role of MIR100HG in Human Disorders

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2023 Jul 24

PMID 37487022

Authors

Soudeh Ghafouri-Fard

Atefeh Harsij

Hossein Farahzadi

Bashdar Mahmud Hussen

Mohammad Taheri

Majid Mokhtari

Affiliations

Soon will be listed here.

Abstract

MIR100HG is a long non-coding RNA (lncRNA) encoded by a locus on chr11:122,028,203-122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF-β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.

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