Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes

Overview

Journal Diabetes

Specialty Endocrinology

Date 2023 Jul 21

PMID 37478166

Authors

Martin Schon

Oana P Zaharia

Klaus Strassburger

Yuliya Kupriyanova

Kalman Bodis

Geronimo Heilmann

Alexander Strom

Gidon J Bonhof

Filippo Michelotti

Iryna Yurchenko

Clara Moser

Maximilian Huttasch

Maria Bombrich

Malte Kelm

Volker Burkart

Vera B Schrauwen-Hinderling

Robert Wagner

Michael Roden

Affiliations

Soon will be listed here.

Abstract

Article Highlights: Intramyocellular lipid content (IMCL) can be elevated in insulin-resistant humans, but its dynamics and association with comorbidities remain unclear. Independently of age, sex, body mass, and skeletal muscle volume, IMCL is higher in recent-onset type 2, but not type 1 diabetes, and remains unchanged within 5 years, despite worsening insulin resistance. A degree of physical fitness modulates the association between IMCL and insulin sensitivity in type 2 diabetes. Whereas higher IMCL associates with lower insulin sensitivity in people with lower physical fitness, there is no association between IMCL and insulin sensitivity in those with higher degree of physical fitness. IMCL associates with progression of microalbuminuria, cardiovascular disease risk, and cardiac autonomic neuropathy.

Citing Articles

Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes.

Kupriyanova Y, Yurchenko I, Bobrov P, Bartels F, Wierichs S, Jonuscheit M BMJ Open Diabetes Res Care. 2025; 13(1).

PMID: 39965871 PMC: 11836859. DOI: 10.1136/bmjdrc-2024-004727.

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