The Number of Prior Pregnancy Losses Does Not Impact Euploidy Rates in Young Patients with Idiopathic Recurrent Pregnancy Loss

Overview

Journal Arch Gynecol Obstet

Specialty Gynecology & Obstetrics

Date 2023 Jul 19

PMID 37466688

Authors

Niyazi Emre Turgut

Fazilet Kubra Boynukalin

Meral Gultomruk

Zalihe Yarkiner

Remzi Abali

Mustafa Bahceci

Affiliations

Soon will be listed here.

Abstract

Purpose: Our study aimed to determine the possible factors that might impact the probability of obtaining a euploid blastocyst following intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A) procedures in idiopathic recurrent pregnancy loss (RPL) patients.

Methods: This single-center retrospective cohort analysis included 180 oocyte retrieval cycles of 166 women under 35 years old and those diagnosed with idiopathic RPL according to American Society of Reproductive Medicine (ASRM) guidelines. Trophectoderm biopsy and next-generation sequencing (NGS) were the techniques used. Patients were stratified by the number of previous losses (Group A: 2, Group B: 3, and Group C: > 3).

Results: Baseline and embryological characteristics showed no statistically significant differences. The euploidy rate per analyzed blastocyst was comparable within the groups (63.3%, 58.2%, and 58.5%; p = 0.477). Logistic regression analyses confirmed that only the trophectoderm scores of A and B increased the probability of obtaining a euploid embryo [OR: 1.82, 95% CI (1.120-2.956), p: 0.016].

Conclusion: It is concluded that there was no correlation between the number of previous losses and the chance of finding at least one euploid embryo in ICSI cycles of women younger than 35 years.

Citing Articles

Preimplantation genetic testing for aneuploidy on previously cryopreserved unbiopsied blastocysts: a cohort study in women with IVF pregnancy loss.

Cai H, Kirshenbaum M, Zhang D, Bai H, Li W, Xue X Reprod Biol Endocrinol. 2025; 23(1):31.

PMID: 40025495 PMC: 11874781. DOI: 10.1186/s12958-025-01371-6.

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