Advances in Regulation and Function of Stearoyl-CoA Desaturase 1 in Cancer, from Bench to Bed

Overview

Journal Sci China Life Sci

Specialties Biology
Science

Date 2023 Jul 14

PMID 37450239

Authors

Zhengyang Guo

Xiao Huo

Xianlong Li

Changtao Jiang

Lixiang Xue

Affiliations

Soon will be listed here.

Abstract

Stearoyl-CoA desaturase 1 (SCD1) converts saturated fatty acids to monounsaturated fatty acids. The expression of SCD1 is increased in many cancers, and the altered expression contributes to the proliferation, invasion, sternness and chemoresistance of cancer cells. Recently, more evidence has been reported to further support the important role of SCD1 in cancer, and the regulation mechanism of SCD1 has also been focused. Multiple factors are involved in the regulation of SCD1, including metabolism, diet, tumor microenvironment, transcription factors, non-coding RNAs, and epigenetics modification. Moreover, SCD1 is found to be involved in regulating ferroptosis resistance. Based on these findings, SCD1 has been considered as a potential target for cancer treatment. However, the resistance of SCD1 inhibition may occur in certain tumors due to tumor heterogeneity and metabolic plasticity. This review summarizes recent advances in the regulation and function of SCD1 in tumors and discusses the potential clinical application of targeting SCD1 for cancer treatment.

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