Circulating Non-coding RNAs and Exosomes: Liquid Biopsies for Monitoring Preeclampsia

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2023 Jul 14

PMID 37450125

Authors

Na Li

Ying Gu

Jiaqi Tang

Yongmei Li

Daozhen Chen

Zhice Xu

Affiliations

Soon will be listed here.

Abstract

Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. The early prediction or accurate diagnosis of PE is a concern of researchers. Liquid biopsy can be analyzed for cell-free nucleic acids and exosomes. Because circulating non-coding RNAs (ncRNAs) and peripheral blood exosomes can be detected in the peripheral blood of women in early pregnancy, these vesicles and their contents have become the focus of research on early predictive and diagnostic biomarkers for preeclampsia. In this review, we focus on recent studies addressing the roles of circulating ncRNAs and exosomes in PE, with particular attention paid to the potential application value of placenta-derived exosomes and circulating ncRNAs as PE-specific biomarkers.

Citing Articles

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Shi H, Wang W, Li F, Guo A, Liu T Noncoding RNA Res. 2024; 9(2):288-293.

PMID: 38505305 PMC: 10945131. DOI: 10.1016/j.ncrna.2024.02.008.

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