Exploration of C-terminal CX3CL1 for Reducing Age-dependent Neurodegeneration

Overview

Journal Neural Regen Res

Date 2023 Jul 14

PMID 37449614

Authors

Jacob Hudobenko

Manoshi Gayen

Marc R Benoit

Neeraj Singh

Riqiang Yan

Affiliations

Soon will be listed here.

References

Fan Q, Gayen M, Singh N, Gao F, He W, Hu X . The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology. J Exp Med. 2019; 216(8):1891-1903. PMC: 6683996. DOI: 10.1084/jem.20182238. View

Rea S, Della-Morte D, Pacifici F, Capuani B, Pastore D, Coppola A . Insulin and Exendin-4 Reduced Mutated Huntingtin Accumulation in Neuronal Cells. Front Pharmacol. 2020; 11:779. PMC: 7270204. DOI: 10.3389/fphar.2020.00779. View

Goncalves R, Wijesekara N, Fraser P, De Felice F . The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Front Cell Neurosci. 2019; 13:17. PMC: 6371747. DOI: 10.3389/fncel.2019.00017. View

Wareham L, Liddelow S, Temple S, Benowitz L, Di Polo A, Wellington C . Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol Neurodegener. 2022; 17(1):23. PMC: 8935795. DOI: 10.1186/s13024-022-00524-0. View

Galle S, van der Spek A, Drent M, Brugts M, Scherder E, Janssen J . Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer's Disease. Front Aging Neurosci. 2019; 11:20. PMC: 6380107. DOI: 10.3389/fnagi.2019.00020. View

Gayen M, Benoit M, Fan Q, Hudobenko J, Yan R . The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling. J Biol Chem. 2022; 298(11):102532. PMC: 9626938. DOI: 10.1016/j.jbc.2022.102532. View

Sheridan G, Murphy K . Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open Biol. 2013; 3(12):130181. PMC: 3877844. DOI: 10.1098/rsob.130181. View

Fan Q, He W, Gayen M, Benoit M, Luo X, Hu X . Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. J Neurosci. 2019; 40(5):1133-1144. PMC: 6989010. DOI: 10.1523/JNEUROSCI.1333-19.2019. View

Hong C, Chen K, Wang W, Chiu J, Wu D, Chao T . Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling. Cells. 2020; 9(3). PMC: 7140619. DOI: 10.3390/cells9030740. View

10.

de la Monte S . Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer's Disease. Drugs. 2016; 77(1):47-65. PMC: 5575843. DOI: 10.1007/s40265-016-0674-0. View

11.

Lalic N, Maric J, Svetel M, Jotic A, Stefanova E, Lalic K . Glucose homeostasis in Huntington disease: abnormalities in insulin sensitivity and early-phase insulin secretion. Arch Neurol. 2008; 65(4):476-80. DOI: 10.1001/archneur.65.4.476. View

12.

Johnson L, Jackson D . The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics. J Cell Sci. 2013; 126(Pt 22):5259-70. PMC: 3828594. DOI: 10.1242/jcs.135343. View