Collateral Sensitivity: An Evolutionary Trade-off Between Antibiotic Resistance Mechanisms, Attractive for Dealing with Drug-resistance Crisis

Overview

Journal Health Sci Rep

Specialty General Medicine

Date 2023 Jul 14

PMID 37448730

Authors

Mina Yekani

Robab Azargun

Simin Sharifi

Edris Nabizadeh

Javid Sadri Nahand

Navideh Karimi Ansari

Mohammad Yousef Memar

Jozsef Soki

Affiliations

Soon will be listed here.

Abstract

Background: The discovery and development of antimicrobial drugs were one of the most significant advances in medicine, but the evolution of microbial resistance limited the efficiency of these drugs.

Aim: This paper reviews the collateral sensitivity in bacteria and its potential and limitation as a new target for treating infections.

Results And Discussion: Knowledge mechanisms of resistance to antimicrobial agents are useful to trace a practical approach to treat and control of resistant pathogens. The effect of a resistance mechanism to certain antibiotics on the susceptibility or resistance to other drugs is a key point that may be helpful for applying a strategy to control resistance challenges. In an evolutionary trade-off known as collateral sensitivity, the resistance mechanism to a certain drug may be mediated by the hypersensitivity to other drugs. Collateral sensitivity has been described for different drugs in various bacteria, but the molecular mechanisms affecting susceptibility are not well demonstrated. Collateral sensitivity could be studied to detect its potential in the battle against resistance crisis as well as in the treatment of pathogens adapting to antibiotics. Collateral sensitivity-based antimicrobial therapy may have the potential to limit the emergence of antibiotic resistance.

Citing Articles

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Collateral sensitivity: An evolutionary trade-off between antibiotic resistance mechanisms, attractive for dealing with drug-resistance crisis.

Yekani M, Azargun R, Sharifi S, Nabizadeh E, Nahand J, Ansari N Health Sci Rep. 2023; 6(7):e1418.

PMID: 37448730 PMC: 10336338. DOI: 10.1002/hsr2.1418.

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