Antiaging Effects of Dietary Supplements and Natural Products

Overview

Journal Front Pharmacol

Date 2023 Jul 13

PMID 37441528

Authors

Lulu Gao

Xudong Liu

Xiaoyan Luo

Xiaofan Lou

Pusen Li

Xian Li

Xiaomeng Liu

Affiliations

Soon will be listed here.

Abstract

Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social and economic development in recent decades, the proportion of the elderly has increased rapidly worldwide, and many aging-related diseases have shown an upward trend, including nervous system diseases, cardiovascular diseases, metabolic diseases, and cancer. The rising burden of aging-related diseases has become an urgent global health challenge and requires immediate attention and solutions. Natural products have been used for a long time to treat various human diseases. The primary cellular pathways that mediate the longevity-extending effects of natural products involve nutrient-sensing pathways. Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. Several studies have reviewed the effects of individual natural compounds on aging and aging-related diseases along with the underlying mechanisms. Natural products from food sources, such as polyphenols, saponins, alkaloids, and polysaccharides, are classified as antiaging compounds that promote health and prolong life various mechanisms. In this article, we have reviewed several recently identified natural products with potential antiaging properties and have highlighted their cellular and molecular mechanisms. The discovery and use of dietary supplements and natural products that can prevent and treat multiple aging-related diseases in humans will be beneficial. Thus, this review provides theoretical background for existing dietary supplements and natural products as potential antiaging agents.

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References

Zhu H, Bian C, Yuan J, Chu W, Xiang X, Chen F . Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury. J Neuroinflammation. 2014; 11:59. PMC: 3986937. DOI: 10.1186/1742-2094-11-59. View

Shi G, Li Y, Cao Q, Wu H, Tang X, Gao X . In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature. Biomed Pharmacother. 2018; 109:1085-1099. DOI: 10.1016/j.biopha.2018.10.130. View

Khan H, Ullah H, Nabavi S . Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects. Food Chem Toxicol. 2018; 124:182-191. DOI: 10.1016/j.fct.2018.12.002. View

Min H, Youn E, Shim Y . Long-Term Caffeine Intake Exerts Protective Effects on Intestinal Aging by Regulating Vitellogenesis and Mitochondrial Function in an Aged Model. Nutrients. 2021; 13(8). PMC: 8398797. DOI: 10.3390/nu13082517. View

Zhang Z, Zhou Y, Fan H, Billy K, Zhao Y, Zhan X . Effects of Lycium barbarum Polysaccharides on Health and Aging of Depend on . Oxid Med Cell Longev. 2019; 2019:6379493. PMC: 6754959. DOI: 10.1155/2019/6379493. View

Hou M, Wang R, Zhao S, Wang Z . Ginsenosides in genus and their biosynthesis. Acta Pharm Sin B. 2021; 11(7):1813-1834. PMC: 8343117. DOI: 10.1016/j.apsb.2020.12.017. View

Yi W, Xie X, Du M, Bu Y, Wu N, Yang H . Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High-Fat Diet via Ketogenesis/SIRT3 Pathway. Oxid Med Cell Longev. 2017; 2017:9032792. PMC: 5549484. DOI: 10.1155/2017/9032792. View

Meng Z, Yu X, Chen J, Li L, Li S . Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activation. Acta Pharmacol Sin. 2014; 35(10):1247-56. PMC: 4186983. DOI: 10.1038/aps.2014.63. View

Abduljawad A, Elawad M, Elkhalifa M, Ahmed A, Hamdoon A, Salim L . Alzheimer's Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms. Molecules. 2022; 27(20). PMC: 9608803. DOI: 10.3390/molecules27206804. View

10.

Si H, Liu D . Dietary antiaging phytochemicals and mechanisms associated with prolonged survival. J Nutr Biochem. 2014; 25(6):581-91. PMC: 4019696. DOI: 10.1016/j.jnutbio.2014.02.001. View

11.

Hosseini A, Razavi B, Banach M, Hosseinzadeh H . Quercetin and metabolic syndrome: A review. Phytother Res. 2021; 35(10):5352-5364. DOI: 10.1002/ptr.7144. View

12.

Escribano-Ferrer E, Queralt Regue J, Garcia-Sala X, Boix Montanes A, Lamuela-Raventos R . In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice. J Nat Prod. 2019; 82(2):177-182. DOI: 10.1021/acs.jnatprod.8b00366. View

13.

Tagde P, Tagde P, Islam F, Tagde S, Shah M, Hussain Z . The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders. Molecules. 2021; 26(23). PMC: 8659038. DOI: 10.3390/molecules26237109. View

14.

Orlandi I, Stamerra G, Strippoli M, Vai M . During yeast chronological aging resveratrol supplementation results in a short-lived phenotype Sir2-dependent. Redox Biol. 2017; 12:745-754. PMC: 5397018. DOI: 10.1016/j.redox.2017.04.015. View

15.

Xia G, Xin N, Liu W, Yao H, Hou Y, Qi J . Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway. Mol Med Rep. 2014; 9(4):1237-41. DOI: 10.3892/mmr.2014.1964. View

16.

Tang Y, Li Y, Yu H, Gao C, Liu L, Xing M . Quercetin attenuates chronic ethanol hepatotoxicity: implication of "free" iron uptake and release. Food Chem Toxicol. 2014; 67:131-8. DOI: 10.1016/j.fct.2014.02.022. View

17.

Juang Y, Liang P . Biological and Pharmacological Effects of Synthetic Saponins. Molecules. 2020; 25(21). PMC: 7663351. DOI: 10.3390/molecules25214974. View

18.

Suckow B, Suckow M . Lifespan extension by the antioxidant curcumin in Drosophila melanogaster. Int J Biomed Sci. 2013; 2(4):402-5. PMC: 3614642. View

19.

Mathur S, Hoskins C . Drug development: Lessons from nature. Biomed Rep. 2017; 6(6):612-614. PMC: 5449954. DOI: 10.3892/br.2017.909. View

20.

He N, Wang P, Wang P, Ma C, Kang W . Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam. BMC Complement Altern Med. 2018; 18(1):261. PMC: 6158911. DOI: 10.1186/s12906-018-2317-3. View