Methods for In Vivo Characterization of Proteostasis in the Mouse Retina

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2023 Jul 13

PMID 37440061

Authors

Yixiao Wang

Ekaterina S Lobanova

Affiliations

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Abstract

An increasing number of studies connect inherited and age-related retinal degenerations with changes in the regulation of proteostasis. Here, we describe technical aspects of existing assays allowing to assess the status of the ubiquitin-proteasome system (UPS), changes in autophagy, and protein translation in mouse retina in vivo. These methods are helpful for the development and testing approaches to modulate proteostasis and delay vision loss.

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