Correlation Between Thyroid Function Indices and Urine Iodine Levels in Patients with Nodular Goiter

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2023 Jul 12

PMID 37434815

Authors

Shifa Yuan

Caixia Liu

Zhijun Liu

Jingtian Wang

Yongqian Xu

Jian Shi

Affiliations

Soon will be listed here.

Abstract

Objective: To retrospectively analyze the iodine nutritional status in patients with nodular goiter (NG) and investigate a possible association between urinary iodine levels and thyroid function indices.

Methods: A total of 173 patients diagnosed with nodular goiter in the Fourth Hospital of Hebei Medical University from January 2019 to May 2021 were selected as the NG group, and 172 healthy individuals without thyroid diseases were selected after a physical examination as a control group. The data of all the participants were retrospectively assessed to explore the association between urinary iodine levels and thyroid function indices. The content of urinary iodine in the two groups was compared, and the correlation of urinary iodine levels with thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in the NG group was evaluated.

Results: The level of urinary iodine in the NG group was 163.97 ± 113.75 μg/L, which was higher than 121.47 ± 53.75 μg/L in the control group (P < 0.05). The iodine excess rate in females was higher than that in males (P < 0.05). The results of Pearson correlation analysis showed that the amount of urinary iodine in patients with hyperthyroidism with different urinary iodine statuses was negatively correlated with the level of TSH and positively correlated with levels of FT3 and FT4.

Conclusion: There is a significant association between urinary iodine levels and thyroid hormone levels in NG patients. Therefore, regular monitoring of urinary iodine levels is essential for the appropriate use of iodine supplementation.

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References

Yildirim Simsir I, Cetinkalp S, Kabalak T . Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma. Med Princ Pract. 2019; 29(1):1-5. PMC: 7024874. DOI: 10.1159/000503575. View

Zhang X, Yuan N, Sun J, Zhao X, Du J, Nan M . Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study. Biol Trace Elem Res. 2021; 200(6):2620-2628. PMC: 9132840. DOI: 10.1007/s12011-021-02887-9. View

V S, M M, B M . The Prevalence of Thyroid Diseases in Pregnancy and it's Relation to Iron Deficiency - A Hospital Based Study. J Assoc Physicians India. 2022; 70(4):11-12. View

Miles E, Vahlberg T, Calder P, Houttu N, Pajunen L, Koivuniemi E . Iodine status in pregnant women and infants in Finland. Eur J Nutr. 2022; 61(6):2919-2927. PMC: 9363324. DOI: 10.1007/s00394-022-02852-9. View

Benvenga S, Guarneri F . Homology of pendrin, sodium-iodide symporter and apical iodide transporter. Front Biosci (Landmark Ed). 2018; 23(10):1864-1873. DOI: 10.2741/4677. View

Mollehave L, Eliasen M, Strele I, Linneberg A, Moreno-Reyes R, Ivanova L . Register-based information on thyroid diseases in Europe: lessons and results from the EUthyroid collaboration. Endocr Connect. 2022; 11(3). PMC: 8942317. DOI: 10.1530/EC-21-0525. View

Huang H, Shi Y, Liang B, Cai H, Cai Q . Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter. Biol Trace Elem Res. 2017; 179(2):165-171. DOI: 10.1007/s12011-017-0960-z. View

Wang S, Liang J, Lin Y, Yao R . Differential expression of the Na(+)/I(-) symporter protein in thyroid cancer and adjacent normal and nodular goiter tissues. Oncol Lett. 2012; 5(1):368-372. PMC: 3525340. DOI: 10.3892/ol.2012.947. View

Chaker L, Razvi S, Bensenor I, Azizi F, Pearce E, Peeters R . Hypothyroidism. Nat Rev Dis Primers. 2022; 8(1):30. DOI: 10.1038/s41572-022-00357-7. View

10.

Meng L, Chen C, Liu Y, Liang X, Zhou J, Xian J . Epidemiological survey of the status of iodine nutrition and thyroid diseases in Guangxi, China. J Trace Elem Med Biol. 2021; 70:126918. DOI: 10.1016/j.jtemb.2021.126918. View

11.

Larsen D, Singh S, Brito M . Thyroid, Diet, and Alternative Approaches. J Clin Endocrinol Metab. 2022; 107(11):2973-2981. DOI: 10.1210/clinem/dgac473. View

12.

Figueiredo W, Lopes E, Jezini D, Marcal L, Assuncao E, Ribeiro Rodrigues P . Differential gene expression profile of multinodular goiter. PLoS One. 2022; 17(5):e0268354. PMC: 9122239. DOI: 10.1371/journal.pone.0268354. View

13.

Fan L, Du Y, Meng F, Liu L, Li M, Liu P . How to Decide the Iodine Content in Salt for a Country-China as an Example. Nutrients. 2022; 14(21). PMC: 9653880. DOI: 10.3390/nu14214606. View

14.

Oberstadt A, Nelson N, Claude A, Refsal K, Scott-Moncrieff J, Petroff B . Radioactive iodine uptake in hyperthyroid cats after administration of recombinant human thyroid stimulating hormone. J Vet Intern Med. 2018; 32(6):1891-1896. PMC: 6271304. DOI: 10.1111/jvim.15295. View

15.

Li Z, Zhang H, Chen W, Li H . Contrast-Enhanced CT-Based Radiomics for the Differentiation of Nodular Goiter from Papillary Thyroid Carcinoma in Thyroid Nodules. Cancer Manag Res. 2022; 14:1131-1140. PMC: 8943619. DOI: 10.2147/CMAR.S353877. View

16.

Agretti P, De Marco G, Ferrarini E, Di Cosmo C, Montanelli L, Bagattini B . Gene expression profile in functioning and non-functioning nodules of autonomous multinodular goiter from an area of iodine deficiency: unexpected common characteristics between the two entities. J Endocrinol Invest. 2021; 45(2):399-411. PMC: 8783917. DOI: 10.1007/s40618-021-01660-y. View

17.

Baloch Z, Asa S, Barletta J, Ghossein R, Juhlin C, Jung C . Overview of the 2022 WHO Classification of Thyroid Neoplasms. Endocr Pathol. 2022; 33(1):27-63. DOI: 10.1007/s12022-022-09707-3. View

18.

Rhodes M, Adams C, Bragg S, Christian N . Thyroid and Parathyroid Conditions: Hyperthyroidism. FP Essent. 2022; 514:11-17. View

19.

Yuan L, Zhao P, Lin X, Yu T, Diao R, Ning G . T1 mapping and reduced field-of-view DWI at 3.0 T MRI for differentiation of thyroid papillary carcinoma from nodular goiter. Clin Physiol Funct Imaging. 2022; 43(3):137-145. DOI: 10.1111/cpf.12803. View

20.

Dardari D, Laborne F, Tourte C, Henry E, Penfornis A . Evaluation of Iodine Supplementation in Pregnant Women with Gestational Diabetes: IODIAB Study. Healthcare (Basel). 2022; 10(12). PMC: 9778216. DOI: 10.3390/healthcare10122388. View