Eurycoma Longifolia Alkaloid Components Ameliorate Hyperuricemic Nephropathy Via Regulating Serum Uric Acid Level and Relieving Inflammatory Reaction

Overview

Journal J Nat Med

Publisher Springer

Date 2023 Jul 11

PMID 37433989

Authors

Dan Wang

Lin Liu

Kaiwen Li

Huiya Cao

Mengyang Liu

Qian Chen

Yuzheng Wu

Yi Zhang

Tao Wang

Affiliations

Soon will be listed here.

Abstract

Hyperuricemia is an independent risk factor for chronic kidney disease. We have previously showed the uric-acid-lowering effect of Eurycoma longifolia Jack, yet the renal protective effect and mechanism of E. longifolia remain obscure. The mouse model of hyperuricemic nephropathy was induced by adenine combined with potassium oxonate in male C57BL/6 J mice. E. Longifolia alkaloid components could reduce the level of serum uric acid by regulating the expression of hepatic phosphoribosyl pyrophosphate synthase (PRPS), hypoxanthine-guanine phosphoribosyl transferase (HPRT), and renal urate transporter organic anion transporter 1 (OAT1) and ATP-binding box subfamily G member 2 (ABCG2) in HN mice. Additionally, E. Longifolia alkaloid components alleviated renal injury and function caused by hyperuricemia, which was characterized by improving renal histopathology, reducing urea nitrogen and creatinine levels. E. Longifolia alkaloid components treatment could reduce the secretion of pro-inflammatory factors by inhibiting the activation of NF-κB and NLRP3 inflammatory signaling pathways, including tumor necrosis factor α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), interleukin-1 β (IL-1β), and regulated activated normal T cell expression and secretion proteins (RANTES). Meanwhile, E. longifolia alkaloid components improved renal fibrosis, inhibited the transformation of calcium-dependent cell adhesion molecule E (E-cadherin) to α-smooth muscle actin (α-SMA) transformation, and decreased collagen 1 expression in HN mice.

Citing Articles

Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment.

Guo J, Lin G, Tang X, Yao J, Feng C, Zuo J Acta Pharmacol Sin. 2025; .

PMID: 39825190 DOI: 10.1038/s41401-024-01459-6.

Research progress on the mechanism of hyperuricemic nephropathy based on multi-omics technique: A review.

Li K, Xia X, Fu T, Ma Y, Wang Y, Fan M Medicine (Baltimore). 2024; 103(51):e40975.

PMID: 39705438 PMC: 11666175. DOI: 10.1097/MD.0000000000040975.

[ (Blume) Miq] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephropathy.

Wang Y, Li K, Yan S, Li G, Cheng M, Chen Q Front Pharmacol. 2024; 15:1485861.

PMID: 39654614 PMC: 11625545. DOI: 10.3389/fphar.2024.1485861.

Evaluation of comparative chemical profiling and bioactivities of medicinal and non-medicinal parts of .

Qiong J, Yang H, Xie Y, Zhu P, Chen G, Zhou Q Heliyon. 2024; 10(12):e32408.

PMID: 39183833 PMC: 11341298. DOI: 10.1016/j.heliyon.2024.e32408.

Association between the serum uric acid/serum creatinine ratio and cognitive function in older adults: NHANES in the United States.

Chen G, Tong L, Ye Q Sci Rep. 2024; 14(1):16312.

PMID: 39009809 PMC: 11251062. DOI: 10.1038/s41598-024-67580-y.

References

Weiner D, Tighiouart H, Elsayed E, Griffith J, Salem D, Levey A . Uric acid and incident kidney disease in the community. J Am Soc Nephrol. 2008; 19(6):1204-11. PMC: 2396939. DOI: 10.1681/ASN.2007101075. View

Obermayr R, Temml C, Gutjahr G, Knechtelsdorfer M, Oberbauer R, Klauser-Braun R . Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol. 2008; 19(12):2407-13. PMC: 2588108. DOI: 10.1681/ASN.2008010080. View

Juraschek S, Kovell L, Miller E, Gelber A . Dose-response association of uncontrolled blood pressure and cardiovascular disease risk factors with hyperuricemia and gout. PLoS One. 2013; 8(2):e56546. PMC: 3584090. DOI: 10.1371/journal.pone.0056546. View

Mazzali M, Hughes J, Kim Y, Jefferson J, Kang D, Gordon K . Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001; 38(5):1101-6. DOI: 10.1161/hy1101.092839. View

Ryu E, Kim M, Shin H, Jang Y, Choi H, Jo I . Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. Am J Physiol Renal Physiol. 2013; 304(5):F471-80. DOI: 10.1152/ajprenal.00560.2012. View

Wang Y, Bao X . Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms. Eur J Med Res. 2013; 18:26. PMC: 3750429. DOI: 10.1186/2047-783X-18-26. View

Jiang L, Zhu Y, Luo X, Wen Y, Du B, Wang M . Epidemiology of acute kidney injury in intensive care units in Beijing: the multi-center BAKIT study. BMC Nephrol. 2019; 20(1):468. PMC: 6915890. DOI: 10.1186/s12882-019-1660-z. View

Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T . Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. EMBO J. 2013; 32(17):2336-47. PMC: 3770333. DOI: 10.1038/emboj.2013.171. View

Yan P, Sun B, Shi H, Zhu W, Zhou Q, Jiang Y . Left atrial and right atrial deformation in patients with coronary artery disease: a velocity vector imaging-based study. PLoS One. 2013; 7(12):e51204. PMC: 3552395. DOI: 10.1371/journal.pone.0051204. View

10.

Chen I, Kuo M, Hwang S, Chang J, Chen H . Allopurinol-induced severe hypersensitivity with acute renal failure. Kaohsiung J Med Sci. 2005; 21(5):228-32. DOI: 10.1016/S1607-551X(09)70192-5. View

11.

Fujimori S, Ooyama K, Ooyama H, Moromizato H . Efficacy of benzbromarone in hyperuricemic patients associated with chronic kidney disease. Nucleosides Nucleotides Nucleic Acids. 2011; 30(12):1035-8. DOI: 10.1080/15257770.2011.622732. View

12.

Thu H, Naina Mohamed I, Hussain Z, Jayusman P, Shuid A . Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies. Chin J Nat Med. 2017; 15(1):71-80. DOI: 10.1016/S1875-5364(17)30010-9. View

13.

Low B, Teh C, Yuen K, Chan K . Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity. Nat Prod Commun. 2011; 6(3):337-41. View

14.

Lahrita L, Kato E, Kawabata J . Uncovering potential of Indonesian medicinal plants on glucose uptake enhancement and lipid suppression in 3T3-L1 adipocytes. J Ethnopharmacol. 2015; 168:229-36. DOI: 10.1016/j.jep.2015.03.082. View

15.

Bao R, Liu M, Wang D, Wen S, Yu H, Zhong Y . Effect of Stem Extract on Uric Acid Excretion in Hyperuricemia Mice. Front Pharmacol. 2020; 10:1464. PMC: 6914847. DOI: 10.3389/fphar.2019.01464. View

16.

Thu H, Hussain Z, Naina Mohamed I, Shuid A . longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells. Curr Drug Targets. 2017; 19(10):1109-1126. DOI: 10.2174/1389450118666170718151913. View

17.

Perez-Ruiz F, Calabozo M, Erauskin G, Ruibal A . Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum. 2003; 47(6):610-3. DOI: 10.1002/art.10792. View

18.

Ou S, Bai K, Cheng W, Chen J, Lin C, Wen H . TGF-β Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPβ Pathways. Int J Mol Sci. 2020; 21(23). PMC: 7731197. DOI: 10.3390/ijms21239084. View

19.

Elfishawi M, Zleik N, Kvrgic Z, Michet Jr C, Crowson C, Matteson E . The Rising Incidence of Gout and the Increasing Burden of Comorbidities: A Population-based Study over 20 Years. J Rheumatol. 2017; 45(4):574-579. PMC: 5880714. DOI: 10.3899/jrheum.170806. View

20.

Tran T, Malainer C, Schwaiger S, Atanasov A, Heiss E, Dirsch V . NF-κB inhibitors from Eurycoma longifolia. J Nat Prod. 2014; 77(3):483-8. PMC: 3971761. DOI: 10.1021/np400701k. View