Paradigm Shift in the Treatment of Meningiomas

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2023 Jul 11

PMID 37432615

Authors

Boris Krischek

Roland Goldbrunner

Affiliations

Soon will be listed here.

Abstract

Meningiomas are the most common brain tumor in adults with rising incidence rates due to an aging population globally, increased availability of neuroimaging, and increased awareness of this condition by treating clinicians and primary care physicians. Surgical resection remains the mainstay of treatment, with adjuvant radiotherapy reserved for higher grade meningiomas or tumors that undergo incomplete resections. Whereas these tumors were classically defined by their histopathological features and subtypes, recent work has uncovered the molecular alterations that may lead to tumor development and have important prognostic implications. However, there remain important clinical questions regarding the management of meningiomas and current clinical guidelines continue to evolve as additional studies add onto the growing body of work that enables us to better understand these tumors.

Citing Articles

The Molecular and Immunological Landscape of Meningiomas.

Lotsch C, Warta R, Herold-Mende C Int J Mol Sci. 2024; 25(17).

PMID: 39273576 PMC: 11394785. DOI: 10.3390/ijms25179631.

References

Simpson D . The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry. 1957; 20(1):22-39. PMC: 497230. DOI: 10.1136/jnnp.20.1.22. View

Sicking J, Voss K, Spille D, Schipmann S, Holling M, Paulus W . The evolution of cranial meningioma surgery-a single-center 25-year experience. Acta Neurochir (Wien). 2018; 160(9):1801-1812. DOI: 10.1007/s00701-018-3617-6. View

Bailo M, Gagliardi F, Boari N, Castellano A, Spina A, Mortini P . The Role of Surgery in Meningiomas. Curr Treat Options Neurol. 2019; 21(10):51. DOI: 10.1007/s11940-019-0587-9. View

Seifert V . Clinical management of petroclival meningiomas and the eternal quest for preservation of quality of life: personal experiences over a period of 20 years. Acta Neurochir (Wien). 2010; 152(7):1099-116. DOI: 10.1007/s00701-010-0633-6. View

Goldbrunner R, Minniti G, Preusser M, Jenkinson M, Sallabanda K, Houdart E . EANO guidelines for the diagnosis and treatment of meningiomas. Lancet Oncol. 2016; 17(9):e383-91. DOI: 10.1016/S1470-2045(16)30321-7. View

Duong L, McCarthy B, McLendon R, Dolecek T, Kruchko C, Douglas L . Descriptive epidemiology of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumors, United States, 2004-2007. Cancer. 2012; 118(17):4220-7. PMC: 4484585. DOI: 10.1002/cncr.27390. View

Davis F, Kupelian V, Freels S, McCarthy B, Surawicz T . Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro Oncol. 2001; 3(3):152-8. PMC: 1920611. DOI: 10.1093/neuonc/3.3.152. View

Porter K, McCarthy B, Freels S, Kim Y, Davis F . Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology. Neuro Oncol. 2010; 12(6):520-7. PMC: 2940648. DOI: 10.1093/neuonc/nop066. View

Elia-Pasquet S, Provost D, Jaffre A, Loiseau H, Vital A, Kantor G . Incidence of central nervous system tumors in Gironde, France. Neuroepidemiology. 2004; 23(3):110-7. DOI: 10.1159/000075953. View

10.

Holleczek B, Zampella D, Urbschat S, Sahm F, von Deimling A, Oertel J . Incidence, mortality and outcome of meningiomas: A population-based study from Germany. Cancer Epidemiol. 2019; 62:101562. DOI: 10.1016/j.canep.2019.07.001. View

11.

Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E . Meningioma. Crit Rev Oncol Hematol. 2008; 67(2):153-71. DOI: 10.1016/j.critrevonc.2008.01.010. View

12.

Wiemels J, Wrensch M, Claus E . Epidemiology and etiology of meningioma. J Neurooncol. 2010; 99(3):307-14. PMC: 2945461. DOI: 10.1007/s11060-010-0386-3. View

13.

Cea-Soriano L, Wallander M, Garcia Rodriguez L . Epidemiology of meningioma in the United Kingdom. Neuroepidemiology. 2012; 39(1):27-34. DOI: 10.1159/000338081. View

14.

Sun T, Plutynski A, Ward S, Rubin J . An integrative view on sex differences in brain tumors. Cell Mol Life Sci. 2015; 72(17):3323-42. PMC: 4531141. DOI: 10.1007/s00018-015-1930-2. View

15.

Morris Z, Whiteley W, Longstreth Jr W, Weber F, Lee Y, Tsushima Y . Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ. 2009; 339:b3016. PMC: 2728201. DOI: 10.1136/bmj.b3016. View

16.

de Boer A, Drewes Y, de Mutsert R, Numans M, den Heijer M, Dekkers O . Incidental findings in research: A focus group study about the perspective of the research participant. J Magn Reson Imaging. 2017; 47(1):230-237. DOI: 10.1002/jmri.25739. View

17.

Suppiah S, Nassiri F, Bi W, Dunn I, Hanemann C, Horbinski C . Molecular and translational advances in meningiomas. Neuro Oncol. 2019; 21(Suppl 1):i4-i17. PMC: 6347079. DOI: 10.1093/neuonc/noy178. View

18.

Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; 131(6):803-20. DOI: 10.1007/s00401-016-1545-1. View

19.

Bi W, Abedalthagafi M, Horowitz P, Agarwalla P, Mei Y, Aizer A . Genomic landscape of intracranial meningiomas. J Neurosurg. 2016; 125(3):525-35. DOI: 10.3171/2015.6.JNS15591. View

20.

Sahm F, Schrimpf D, Stichel D, Jones D, Hielscher T, Schefzyk S . DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. Lancet Oncol. 2017; 18(5):682-694. DOI: 10.1016/S1470-2045(17)30155-9. View