Influence of Green Tea Added to Cherry Wine on Phenolic Content, Antioxidant Activity and Alpha-Glucosidase Inhibition During an In Vitro Gastrointestinal Digestion

Overview

Journal Foods

Specialty Biotechnology

Date 2023 Jul 11

PMID 37431046

Authors

Malgorzata Lasik-Kurdys

Malgorzata Gumienna

Barbara Gorna

Noranizan Mohd Adzahan

Affiliations

Soon will be listed here.

Abstract

Cherries are a good source of bioactive compounds, with high antioxidant activity as well as nutritional and therapeutic importance. In this study, cherry wines enriched with green tea infusion (mild and concentrated) were produced, and their biological properties were evaluated. During winemaking, the main vinification parameters (alcohol, reducing sugars, acidity, total polyphenol content) as well biological activity (antioxidant activity, alpha-glucosidase inhibition potential) were determined. An in vitro digestion process was also performed to evaluate the impact of the gastrointestinal environment on the biological stability of the wines, and to analyze the interactions of wine-intestinal microflora. The addition of green tea to the cherry wine significantly increased the total polyphenol content (up to 2.73 g GAE/L) and antioxidant activity (up to 22.07 mM TE/L), compared with the control wine. However, after in vitro digestion, a reduction in total polyphenols (53-64%) and antioxidant activity (38-45%) were noted. Wines fortified with green tea expressed a stronger inhibition effect on intestinal microflora growth, of which were the most sensitive microorganisms. The tea-derived bioactive compounds significantly increased the potential of alpha-glucosidase inhibition. The proposed wines could be a good alternative type of wine, with an increased polyphenol content and the potential to control the insulin response supporting therapy for diabetes.

Citing Articles

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References

Milutinovic M, Dimitrijevic-Brankovic S, Rajilic-Stojanovic M . Plant Extracts Rich in Polyphenols as Potent Modulators in the Growth of Probiotic and Pathogenic Intestinal Microorganisms. Front Nutr. 2021; 8:688843. PMC: 8366775. DOI: 10.3389/fnut.2021.688843. View

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M . Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999; 26(9-10):1231-7. DOI: 10.1016/s0891-5849(98)00315-3. View

Tamargo A, Cueva C, Silva M, Molinero N, Miralles B, Bartolome B . Gastrointestinal co-digestion of wine polyphenols with glucose/whey proteins affects their bioaccessibility and impact on colonic microbiota. Food Res Int. 2022; 155:111010. DOI: 10.1016/j.foodres.2022.111010. View

Wang L, Zhang B, Xiao J, Huang Q, Li C, Fu X . Physicochemical, functional, and biological properties of water-soluble polysaccharides from Rosa roxburghii Tratt fruit. Food Chem. 2018; 249:127-135. DOI: 10.1016/j.foodchem.2018.01.011. View

Silva R, Pogacnik L . Polyphenols from Food and Natural Products: Neuroprotection and Safety. Antioxidants (Basel). 2020; 9(1). PMC: 7022568. DOI: 10.3390/antiox9010061. View

Kang M, Oh J, Kang I, Hong S, Choi C . Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008; 46(6):744-50. DOI: 10.1007/s12275-008-0235-7. View

Johnson M, Lucius A, Meyer T, Gonzalez de Mejia E . Cultivar evaluation and effect of fermentation on antioxidant capacity and in vitro inhibition of α-amylase and α-glucosidase by highbush blueberry (Vaccinium corombosum). J Agric Food Chem. 2011; 59(16):8923-30. DOI: 10.1021/jf201720z. View

Rivero-Perez M, Muniz P, Gonzalez-Sanjose M . Contribution of anthocyanin fraction to the antioxidant properties of wine. Food Chem Toxicol. 2008; 46(8):2815-22. DOI: 10.1016/j.fct.2008.05.014. View

Pantelic M, Dabic D, Matijasevic S, Davidovic S, Dojcinovic B, Milojkovic-Opsenica D . Chemical characterization of fruit wine made from Oblačinska sour cherry. ScientificWorldJournal. 2014; 2014:454797. PMC: 4101208. DOI: 10.1155/2014/454797. View

10.

Xiao J, Kai G, Yamamoto K, Chen X . Advance in dietary polyphenols as α-glucosidases inhibitors: a review on structure-activity relationship aspect. Crit Rev Food Sci Nutr. 2013; 53(8):818-36. DOI: 10.1080/10408398.2011.561379. View

11.

Cardona F, Andres-Lacueva C, Tulipani S, Tinahones F, Queipo-Ortuno M . Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013; 24(8):1415-22. DOI: 10.1016/j.jnutbio.2013.05.001. View

12.

Hossain U, Das A, Ghosh S, Sil P . An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications. Food Chem Toxicol. 2020; 145:111738. PMC: 7480666. DOI: 10.1016/j.fct.2020.111738. View

13.

Zhang Q, Zhang J, Zhang J, Xu D, Li Y, Liu Y . Antimicrobial Effect of Tea Polyphenols against Foodborne Pathogens: A Review. J Food Prot. 2021; 84(10):1801-1808. DOI: 10.4315/JFP-21-043. View

14.

Knarreborg A, Simon M, Engberg R, Borg Jensen B, Tannock G . Effects of dietary fat source and subtherapeutic levels of antibiotic on the bacterial community in the ileum of broiler chickens at various ages. Appl Environ Microbiol. 2002; 68(12):5918-24. PMC: 134372. DOI: 10.1128/AEM.68.12.5918-5924.2002. View

15.

McDougall G, Fyffe S, Dobson P, Stewart D . Anthocyanins from red wine--their stability under simulated gastrointestinal digestion. Phytochemistry. 2005; 66(21):2540-8. DOI: 10.1016/j.phytochem.2005.09.003. View

16.

Gumienna M, Lasik M, Czarnecki Z . Bioconversion of grape and chokeberry wine polyphenols during simulated gastrointestinal in vitro digestion. Int J Food Sci Nutr. 2010; 62(3):226-33. DOI: 10.3109/09637486.2010.532115. View

17.

Samtiya M, Aluko R, Dhewa T, Moreno-Rojas J . Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview. Foods. 2021; 10(4). PMC: 8068854. DOI: 10.3390/foods10040839. View

18.

Zhang L, Han Z, Granato D . Polyphenols in foods: Classification, methods of identification, and nutritional aspects in human health. Adv Food Nutr Res. 2021; 98:1-33. DOI: 10.1016/bs.afnr.2021.02.004. View

19.

Oboh G, Agunloye O, Adefegha S, Akinyemi A, Ademiluyi A . Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J Basic Clin Physiol Pharmacol. 2014; 26(2):165-70. DOI: 10.1515/jbcpp-2013-0141. View

20.

Goncalves A, Flores-Felix J, Costa A, Falcao A, Alves G, Silva L . Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco). Foods. 2021; 10(11). PMC: 8621173. DOI: 10.3390/foods10112623. View