Characterization of in Northern Vietnam in 2012-2016

Overview

Journal Access Microbiol

Specialty Microbiology

Date 2023 Jul 10

PMID 37424561

Authors

Dong Tu Nguyen

Masatomo Morita

Tuan Cuong Ngo

Thanh Huong Le

Dang Hai Le

Hoai Thu Nguyen

Yukihiro Akeda

Makoto Ohnishi

Hidemasa Izumiya

Affiliations

Soon will be listed here.

Abstract

Introduction: Shigellosis remains a considerable public health concern in developing countries. and are prevalent worldwide and has been replacing .

Gap Statement: still causes outbreaks of shigellosis in northern Vietnam but limited information is available on its genetic characteristics.

Aim: This study aimed to characterize the genetic characteristics of strains from northern Vietnam.

Methodology: This study used 17 isolates from eight incidents, collected in northern Vietnam between 2012 and 2016. The samples were subjected to whole genome sequencing, molecular serotyping, cluster analysis and identification of antimicrobial resistance genes. Additionally, phylogenetic analysis was performed including isolates from previous studies.

Results: Clusters were identified according to spatiotemporal backgrounds. The results suggested that two incidents in Yen Bai province in 2015 and 2016 were derived from a very recent common ancestor. All isolates belonged to phylogroup (PG) 3, which was divided into two sub-lineages. Thirteen of 17 isolates, including those from the Yen Bai incidents, belonged to sub-lineage Sub-1 and were serotyped as 1a. The remaining four isolates belonged to sub-lineage Sub-2 and were the globally predominant serotype 2a. The Sub-1 isolates possessed the gene, which encodes the glycosyl transferase that determines serotype 1a, with bacteriophage elements in the vicinity.

Conclusion: This study revealed two PG3 sub-lineages of in northern Vietnam, of which Sub-1 might be specific to the region.

Citing Articles

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