Fecal Acute Phase Proteins in Cats with Chronic Enteropathies

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2023 Jul 4

PMID 37401847

Authors

Dimitra A Karra

Chris C Chadwick

Evangelia M Stavroulaki

Matina N Pitropaki

Evgenia Flouraki

Karin Allenspach

Jonathan A Lidbury

Joerg M Steiner

Panagiotis G Xenoulis

Affiliations

Soon will be listed here.

Abstract

Background: Chronic enteropathies (CE) are common in cats and reliable biomarkers that can distinguish different causes and predict or monitor response to treatment are currently lacking.

Hypothesis: To evaluate certain acute phase proteins in feces that could potentially be used as biomarkers in cats with CE.

Animals: Twenty-eight cats with either inflammatory bowel disease (IBD; n = 13), food-responsive enteropathy (FRE; n = 3) or small cell gastrointestinal lymphoma (SCGL; n = 12) and 29 healthy control cats were prospectively enrolled.

Methods: Fecal concentrations of haptoglobin, alpha-1-acid-glycoprotein (AGP), pancreatitis-associated protein-1 (PAP-1), ceruloplasmin, and C-reactive protein (CRP) were measured using Spatial Proximity Analyte Reagent Capture Luminescence (SPARCL) immunoassays before and after initiation of treatment. Cats were treated with diet and/or prednisolone (IBD cats), plus chlorambucil (SCGL cats).

Results: Compared with controls, median fecal AGP concentrations were significantly lower (25.1 vs 1.8 μg/g; P = .003) and median fecal haptoglobin (0.17 vs 0.5 μg/g), PAP-1 (0.04 vs 0.4 μg/g) and ceruloplasmin (0.15 vs 4.2 μg/g) concentrations were significantly higher (P < .001) in cats with CE. Median fecal AGP concentrations were significantly lower (P = .01) in cats with IBD and FRE (0.6 μg/g) compared with cats with SCGL (10.75 μg/g). A significant reduction was found in CE cats after treatment for median fecal ceruloplasmin concentrations (6.36 vs 1.16 μg/g; P = .04).

Conclusions: Fecal AGP concentration shows promise to differentiate cats with SCGL from cats with IBD and FRE. Fecal ceruloplasmin concentrations may be useful to objectively monitor response to treatment in cats with CE.

Citing Articles

Evaluation of the fatty acid-based erythrocyte membrane lipidome in cats with food responsive enteropathy, inflammatory bowel disease and low-grade intestinal T-cell lymphoma.

Crisi P, Giordano M, Luciani A, Gramenzi A, Prasinou P, Sansone A PLoS One. 2024; 19(7):e0307757.

PMID: 39074116 PMC: 11285949. DOI: 10.1371/journal.pone.0307757.

Fecal acute phase proteins in cats with chronic enteropathies.

Karra D, Chadwick C, Stavroulaki E, Pitropaki M, Flouraki E, Allenspach K J Vet Intern Med. 2023; 37(5):1750-1759.

PMID: 37401847 PMC: 10473003. DOI: 10.1111/jvim.16802.

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