Dendritic Excitations Govern Back-propagation Via a Spike-rate Accelerometer

Overview

Journal bioRxiv

Date 2023 Jul 3

PMID 37398232

Authors

Pojeong Park

David Wong-Campos

Daniel G Itkis

Byung Hun Lee

Yitong Qi

Hunter Davis

Benjamin Antin

Amol Pasarkar

Jonathan B Grimm

Sarah E Plutkis

Katie L Holland

Liam Paninski

Luke D Lavis

Adam E Cohen

Affiliations

Soon will be listed here.

Abstract

Dendrites on neurons support nonlinear electrical excitations, but the computational significance of these events is not well understood. We developed molecular, optical, and analytical tools to map sub-millisecond voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons under diverse optogenetic and synaptic stimulus patterns, in acute brain slices. We observed history-dependent spike back-propagation in distal dendrites, driven by locally generated Na spikes (dSpikes). Dendritic depolarization created a transient window for dSpike propagation, opened by A-type channel inactivation, and closed by slow inactivation. Collisions of dSpikes with synaptic inputs triggered calcium channel and N-methyl-D-aspartate receptor (NMDAR)-dependent plateau potentials, with accompanying complex spikes at the soma. This hierarchical ion channel network acts as a spike-rate accelerometer, providing an intuitive picture of how dendritic excitations shape associative plasticity rules.

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