Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells Through Metabolic Rewiring

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Jun 28

PMID 37377608

Authors

Jean Nakhle

Khattar Khattar

Tulin Ozkan

Adel Boughlita

Daouda Abba Moussa

Amelie Darlix

Frederique Lorcy

Valerie Rigau

Luc Bauchet

Sabine Gerbal-Chaloin

Martine Daujat-Chavanieu

Floriant Bellvert

Laurent Turchi

Thierry Virolle

Jean-Philippe Hugnot

Nicolas Buisine

Mireille Galloni

Valerie Dardalhon

Anne-Marie Rodriguez

Marie-Luce Vignais

Affiliations

Soon will be listed here.

Abstract

Significance: Mitochondria acquired from MSCs enhance the chemoresistance of GBMs. The discovery that they also generate metabolic vulnerability in GSCs paves the way for novel therapeutic approaches.

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