Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2023 Jun 27

PMID 37367648

Authors

Leonel Pereira

Joao Cotas

Affiliations

Soon will be listed here.

Abstract

Polyphenols are compounds found in various plants and foods, known for their antioxidant and anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols and other minor nutrients that are found in algae, fish and crustaceans. These compounds have unique chemical structures and exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial and antitumor action. Due to these properties, marine polyphenols are being investigated as possible therapeutic agents for the treatment of a wide variety of conditions, such as cardiovascular disease, diabetes, neurodegenerative diseases and cancer. This review focuses on the therapeutic potential of marine polyphenols and their applications in human health, and also, in marine phenolic classes, the extraction methods, purification techniques and future applications of marine phenolic compounds.

Citing Articles

Plant Polyphenols as Heart's Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action.

Stankovic S, Mutavdzin Krneta S, Djuric D, Milosevic V, Milenkovic D Int J Mol Sci. 2025; 26(3).

PMID: 39940685 PMC: 11816429. DOI: 10.3390/ijms26030915.

Abiotic Factors Modulating Metabolite Composition in Brown Algae (Phaeophyceae): Ecological Impacts and Opportunities for Bioprospecting of Bioactive Compounds.

Lopes C, Obando J, Santos T, Cavalcanti D, Teixeira V Mar Drugs. 2024; 22(12).

PMID: 39728119 PMC: 11677006. DOI: 10.3390/md22120544.

Optimization of Combined Ultrasound and Microwave-Assisted Extraction for Enhanced Bioactive Compounds Recovery from Four Medicinal Plants: Oregano, Rosemary, Hypericum, and Chamomile.

Laina K, Drosou C, Stergiopoulos C, Eleni P, Krokida M Molecules. 2024; 29(23).

PMID: 39683930 PMC: 11643802. DOI: 10.3390/molecules29235773.

Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease (IBD): focus on the NF-ƙB and JAK/STAT pathways.

Ismail E, Zakuan N, Othman Z, Vidyadaran S, Mohammad H, Ishak R Inflammopharmacology. 2024; 33(2):759-765.

PMID: 39636381 PMC: 11842400. DOI: 10.1007/s10787-024-01607-8.

Effects of Marine-Derived Components on Cardiovascular Disease Risk Factors and Gut Microbiota Diversity.

Lamminpaa I, Amedei A, Parolini C Mar Drugs. 2024; 22(11).

PMID: 39590803 PMC: 11595733. DOI: 10.3390/md22110523.

References

Kubanek J, Prusak A, Snell T, Giese R, Hardcastle K, Fairchild C . Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus. Org Lett. 2005; 7(23):5261-4. PMC: 3374863. DOI: 10.1021/ol052121f. View

Heydarzadeh S, Kheradmand Kia S, Zarkesh M, Pakizehkar S, Hosseinzadeh S, Hedayati M . The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer. Oxid Med Cell Longev. 2022; 2022:2724324. PMC: 9098327. DOI: 10.1155/2022/2724324. View

Puspita M, Deniel M, Widowati I, Radjasa O, Douzenel P, Marty C . Total phenolic content and biological activities of enzymatic extracts from (Yendo) Fensholt. J Appl Phycol. 2020; 29(5):2521-2537. PMC: 7088061. DOI: 10.1007/s10811-017-1086-6. View

Lavoie S, Sweeney-Jones A, Mojib N, Dale B, Gagaring K, McNamara C . Antibacterial Oligomeric Polyphenols from the Green Alga Cladophora socialis. J Org Chem. 2019; 84(9):5035-5045. PMC: 6503470. DOI: 10.1021/acs.joc.8b03218. View

Fonseca S, Amaral M, Reis C, Custodio L . Marine Natural Products as Innovative Cosmetic Ingredients. Mar Drugs. 2023; 21(3). PMC: 10054431. DOI: 10.3390/md21030170. View

Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M . Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res. 2014; 29(3):323-31. DOI: 10.1002/ptr.5256. View

Aubourg S . Enhancement of Lipid Stability and Acceptability of Canned Seafood by Addition of Natural Antioxidant Compounds to the Packing Medium-A Review. Antioxidants (Basel). 2023; 12(2). PMC: 9952551. DOI: 10.3390/antiox12020245. View

Whitfield F, Helidoniotis F, Shaw K, Svoronos D . Distribution of bromophenols in species of marine algae from eastern Australia. J Agric Food Chem. 2000; 47(6):2367-73. DOI: 10.1021/jf981080h. View

Freitas R, Martins A, Silva J, Alves C, Pinteus S, Alves J . Highlighting the Biological Potential of the Brown Seaweed for Skin Applications. Antioxidants (Basel). 2020; 9(7). PMC: 7402176. DOI: 10.3390/antiox9070611. View

10.

Duda-Chodak A, Tarko T . Possible Side Effects of Polyphenols and Their Interactions with Medicines. Molecules. 2023; 28(6). PMC: 10058246. DOI: 10.3390/molecules28062536. View

11.

Luo J, Hou Y, Xie M, Ma W, Shi D, Jiang B . CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes. Mar Drugs. 2020; 18(5). PMC: 7281472. DOI: 10.3390/md18050267. View

12.

Wozniak L, Skapska S, Marszalek K . Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities. Molecules. 2015; 20(11):20614-41. PMC: 6332387. DOI: 10.3390/molecules201119721. View

13.

Santaniello G, Nebbioso A, Altucci L, Conte M . Recent Advancement in Anticancer Compounds from Marine Organisms: Approval, Use and Bioinformatic Approaches to Predict New Targets. Mar Drugs. 2023; 21(1). PMC: 9862894. DOI: 10.3390/md21010024. View

14.

Karpinski T, Adamczak A . Fucoxanthin-An Antibacterial Carotenoid. Antioxidants (Basel). 2019; 8(8). PMC: 6720875. DOI: 10.3390/antiox8080239. View

15.

Dyshlovoy S . Recent Updates on Marine Cancer-Preventive Compounds. Mar Drugs. 2021; 19(10). PMC: 8537284. DOI: 10.3390/md19100558. View

16.

Kaczmarek-Szczepanska B, Grabska-Zielinska S, Michalska-Sionkowska M . The Application of Phenolic Acids in The Obtainment of Packaging Materials Based on Polymers-A Review. Foods. 2023; 12(6). PMC: 10048273. DOI: 10.3390/foods12061343. View

17.

Perez-Alva A, Baigts-Allende D, Ramirez-Rodrigues M, Ramirez-Rodrigues M . Effect of Brown Seaweed () Addition on Nutritional and Quality Characteristics of Yellow, Blue, and Red Maize Tortillas. Foods. 2022; 11(17). PMC: 9455798. DOI: 10.3390/foods11172627. View

18.

Nag M, Lahiri D, Dey A, Sarkar T, Pati S, Joshi S . Seafood Discards: A Potent Source of Enzymes and Biomacromolecules With Nutritional and Nutraceutical Significance. Front Nutr. 2022; 9:879929. PMC: 9024408. DOI: 10.3389/fnut.2022.879929. View

19.

Tagde P, Tagde P, Islam F, Tagde S, Shah M, Hussain Z . The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders. Molecules. 2021; 26(23). PMC: 8659038. DOI: 10.3390/molecules26237109. View

20.

Lee M, Kwon M, Choi J, Shin T, No H, Choi J . Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. J Agric Food Chem. 2012; 60(36):9120-9. DOI: 10.1021/jf3022018. View