An Integrative Mathematical Model for Timing Treatment Toxicity and Zeitgeber Impact in Colorectal Cancer Cells

Overview

Journal NPJ Syst Biol Appl

Specialty Biology

Date 2023 Jun 23

PMID 37353516

Authors

Janina Hesse

Tim Muller

Angela Relogio

Affiliations

Soon will be listed here.

Abstract

Increasing evidence points to a role of the circadian clock in the regulation of cancer hallmarks with a strong impact on the understanding and treatment of this disease. Anti-cancer treatment can be personalized considering treatment timing. Here we present a new mathematical model based on data from three colorectal cancer cell lines and core-clock knock-outs, which couples the circadian and drug metabolism network, and that allows to determine toxicity profiles for a given drug and cell type. Moreover, this model integrates external Zeitgebers and thus may be used to fine-tune toxicity by using external factors, such as light, and therefore, to a certain extent, help fitting the endogenous rhythms of the patients to a defined clinic routine facilitating the implementation of time-dependent treatment in clinical practice.

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