Carcinogenic Roles of MAFG-AS1 in Human Cancers

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2023 Jun 23

PMID 37351806

Authors

Mohsen Ahmadi

Firouzeh Morshedzadeh

Sayyed Mohammad Hossein Ghaderian

Pegah Mousavi

Leila Habibipour

Maryam Peymani

Mohammad Reza Abbaszadegan

Soudeh Ghafouri-Fard

Affiliations

Soon will be listed here.

Abstract

The MAF bZIP transcription factor G-antisense RNA 1 (MAFG-AS1) is located on chromosome 17. MAFG-AS1 was upregulated in 15 human cancers. MAFG-AS1 not only suppresses 16 miRNAs but also directly impacts 22 protein-coding genes' expression. Notably, abnormal MAFG-AS1 expression is connected to clinicopathological characteristics and a worse prognosis in a variety of cancers. Moreover, MAFG-AS1 takes its part in the tumorigenesis and progression of various human malignancies by suppressing apoptosis and promoting proliferation, migration, invasion, aerobic glycolysis, ferroptosis, angiogenesis, EMT, and metastasis. Besides, it can predict treatment effectiveness in ER + breast cancer, urothelial bladder carcinoma, and liver cancer by functioning as a trigger of resistance to tamoxifen, sorafenib, and cisplatin. This study systematically presents the functions of MAFG-AS1 in various cancers, as well as the findings of bioinformatics analyses of the MAFG-AS1, which should give clear advice for future research.

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