Long Non-coding RNA MAFG-AS1 Promotes Proliferation and Metastasis of Breast Cancer by Modulating STC2 Pathway

Overview

Journal Cell Death Discov

Date 2022 May 5

PMID 35513366

Authors

Shihao Di

Rumeng Bai

Die Lu

Chunni Chen

Tianshi Ma

Zigui Zou

Zhihong Zhang

Affiliations

Soon will be listed here.

Abstract

Breast cancer is the most common cancer worldwide. A number of studies proposed that long non-coding RNA plays an essential role in the regulation of invasion and metastasis of various forms of malignancy, including lung cancer, gastric cancer, and bladder cancer. In this study, a long non-coding RNA(LncRNA) MAFG-AS1 was explored in detail to understand the significance in the etiology of breast cancer. The results indicated that expression of LncRNA MAFG-AS1 in the breast cancer tissues was significantly higher than the adjacent normal breast tissues and elevated expression level of LncRNA MAFG-AS1 was correlated to the larger tumor size, negative expression of ER, PR and lymph node metastasis. The potency of breast cancer proliferation, invasion, and metastasis was inhibited in the absence of LncRNA MAFG-AS1. Mechanically, LncRNA MAFG-AS1 was mainly located in the cytoplasm. The downstream target gene of LncRNA MAFG-AS1 was STC2 which might promote cell proliferation and metastasis in breast cancer and this study provides a new potential therapeutic target for breast cancer.

Citing Articles

STC2 suppresses triple-negative breast cancer migration and invasion by inhibition on EMT and promotion on cell apoptosis.

Lei R, Yao C, Huang R, Wu W, Ou L, Yang C Discov Oncol. 2024; 15(1):339.

PMID: 39117970 PMC: 11310179. DOI: 10.1007/s12672-024-01196-6.

Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS.

Swaminathan G, Rogel-Ayala D, Armich A, Barreto G Cancers (Basel). 2024; 16(5).

PMID: 38473229 PMC: 10930775. DOI: 10.3390/cancers16050868.

Correlation between long non-coding RNA MAFG-AS1 and cancer prognosis: a meta-analysis.

Lin G, Liu H, Lin J, Liu X, Xu L Front Oncol. 2023; 13:1286610.

PMID: 38130989 PMC: 10733508. DOI: 10.3389/fonc.2023.1286610.

LncRNA MAFG-AS1 is involved in human cancer progression.

Li P, Ma X, Gu X Eur J Med Res. 2023; 28(1):497.

PMID: 37941063 PMC: 10631199. DOI: 10.1186/s40001-023-01486-9.

Palbociclib sensitizes ER-positive breast cancer cells to fulvestrant by promoting the ubiquitin-mediated degradation of ER-α via SNHG17/Hippo-YAP axis.

Lei L, Huang Y, Shi L, Ye W, Lv X, Ying L Breast Cancer Res Treat. 2023; 203(3):613-625.

PMID: 37924380 PMC: 10806073. DOI: 10.1007/s10549-023-07138-0.

References

Tripathi S, Levine H, Jolly M . The Physics of Cellular Decision Making During Epithelial-Mesenchymal Transition. Annu Rev Biophys. 2020; 49:1-18. DOI: 10.1146/annurev-biophys-121219-081557. View

Li J, Liu Z, Zhang R, Ma S, Lin T, Li Y . Sp1 contributes to overexpression of stanniocalcin 2 through regulation of promoter activity in colon adenocarcinoma. World J Gastroenterol. 2019; 25(22):2776-2787. PMC: 6580349. DOI: 10.3748/wjg.v25.i22.2776. View

Yang F, Shen Y, Zhang W, Jin J, Huang D, Fang H . An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer. Cell Death Differ. 2018; 25(12):2209-2220. PMC: 6261952. DOI: 10.1038/s41418-018-0123-6. View

Zuo Y, Li Y, Zhou Z, Ma M, Fu K . Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer. Biomed Pharmacother. 2017; 95:922-928. DOI: 10.1016/j.biopha.2017.09.005. View

Joshi A, Hossain E, Elferink C . Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression. Mol Pharmacol. 2017; 92(3):366-374. PMC: 5553190. DOI: 10.1124/mol.117.108878. View

Niu Y, Bao L, Chen Y, Wang C, Luo M, Zhang B . HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis. Cancer Res. 2020; 80(5):964-975. PMC: 7056556. DOI: 10.1158/0008-5472.CAN-19-1532. View

Sui Y, Lin G, Zheng Y, Huang W . LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis. Eur J Pharmacol. 2019; 859:172465. DOI: 10.1016/j.ejphar.2019.172465. View

Sun G, Liu M, Han H . Overexpression of microRNA-190 inhibits migration, invasion, epithelial-mesenchymal transition, and angiogenesis through suppression of protein kinase B-extracellular signal-regulated kinase signaling pathway via binding to stanniocalicin 2 in.... J Cell Physiol. 2019; 234(10):17824-17838. DOI: 10.1002/jcp.28409. View

Roche F, Pietila I, Kaito H, Sjostrom E, Sobotzki N, Noguer O . Leukocyte Differentiation by Histidine-Rich Glycoprotein/Stanniocalcin-2 Complex Regulates Murine Glioma Growth through Modulation of Antitumor Immunity. Mol Cancer Ther. 2018; 17(9):1961-1972. DOI: 10.1158/1535-7163.MCT-18-0097. View

10.

Wang Z, Chen M, Pan J, Wang X, Chen X, Shen K . Pattern of distant metastases in inflammatory breast cancer - A large-cohort retrospective study. J Cancer. 2020; 11(2):292-300. PMC: 6930435. DOI: 10.7150/jca.34572. View

11.

Zhang S, Sun K, Zheng R, Zeng H, Wang S, Chen R . Cancer incidence and mortality in China, 2015. J Natl Cancer Cent. 2024; 1(1):2-11. PMC: 11256613. DOI: 10.1016/j.jncc.2020.12.001. View

12.

Sha S, Yuan D, Liu Y, Han B, Zhong N . Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression. Biol Open. 2017; 6(9):1310-1316. PMC: 5612229. DOI: 10.1242/bio.023135. View

13.

He H, Qie S, Guo Q, Chen S, Zou C, Lu T . Stanniocalcin 2 (STC2) expression promotes post-radiation survival, migration and invasion of nasopharyngeal carcinoma cells. Cancer Manag Res. 2019; 11:6411-6424. PMC: 6636319. DOI: 10.2147/CMAR.S197607. View

14.

Zhao J, Jiao Y, Song Y, Liu J, Li X, Zhang H . Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling. Front Physiol. 2018; 9:873. PMC: 6046442. DOI: 10.3389/fphys.2018.00873. View

15.

Wang P, Chou C, Lin C, Yao Y, Cheng H, Li H . A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer. Oncogene. 2018; 37(34):4662-4678. DOI: 10.1038/s41388-018-0293-1. View

16.

Sun Z, Zhang T, Chen B . Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Proliferation and Metastasis of Osteosarcoma Cells by Targeting c-Met and SOX4 via miR-34a/c-5p and miR-449a/b. Med Sci Monit. 2019; 25:1410-1422. PMC: 6396440. DOI: 10.12659/MSM.912703. View

17.

Huang Y, Guo Q, Ding X, Wang X . Mechanism of long noncoding RNAs as transcriptional regulators in cancer. RNA Biol. 2020; 17(11):1680-1692. PMC: 7567497. DOI: 10.1080/15476286.2019.1710405. View

18.

Shima H, Kida K, Adachi S, Yamada A, Sugae S, Narui K . Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness. Breast Cancer Res Treat. 2018; 170(3):507-516. DOI: 10.1007/s10549-018-4793-z. View

19.

Liu Y, Wei G, Ma Q, Han Y . Knockdown of long noncoding RNA TP73-AS1 suppresses the malignant progression of breast cancer cells in vitro through targeting miRNA-125a-3p/metadherin axis. Thorac Cancer. 2020; 11(2):394-407. PMC: 6996984. DOI: 10.1111/1759-7714.13283. View

20.

Zhang K, Liu P, Tang H, Xie X, Kong Y, Song C . AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer. Front Pharmacol. 2018; 9:1248. PMC: 6250734. DOI: 10.3389/fphar.2018.01248. View