Human Circulating and Tissue-resident Memory CD8 T Cells

Overview

Journal Nat Immunol

Date 2023 Jun 22

PMID 37349380

Authors

Marcus Buggert

David A Price

Laura K Mackay

Michael R Betts

Affiliations

Soon will be listed here.

Abstract

Our current knowledge of human memory CD8 T cells is derived largely from studies of the intravascular space. However, emerging data are starting to challenge some of the dogmas based on this work, suggesting that a conceptual revision may be necessary. In this review, we provide a brief history of the field and summarize the biology of circulating and tissue-resident memory CD8 T cells, which are ultimately responsible for effective immune surveillance. We also incorporate recent findings into a biologically integrated model of human memory CD8 T cell differentiation. Finally, we address how future innovative human studies could improve our understanding of anatomically localized CD8 T cells to inform the development of more effective immunotherapies and vaccines, the need for which has been emphasized by the global struggle to contain severe acute respiratory syndrome coronavirus 2.

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