A Defect in Mitochondrial Complex III but Not in Complexes I or IV Causes Early β-Cell Dysfunction and Hyperglycemia in Mice

Overview

Journal Diabetes

Specialty Endocrinology

Date 2023 Jun 21

PMID 37343239

Authors

Anna L Lang

Nadee Nissanka

Ruy A Louzada

Alejandro Tamayo

Elizabeth Pereira

Carlos T Moraes

Alejandro Caicedo

Affiliations

Soon will be listed here.

Abstract

Article Highlights: Mitochondrial metabolism is critical for β-cell insulin secretion, and mitochondrial dysfunction is involved in type 2 diabetes pathogenesis. We determined whether individual oxidative phosphorylation complexes contribute uniquely to β-cell function. Compared with loss of complex I and IV, loss of complex III resulted in severe in vivo hyperglycemia and altered β-cell redox status. Loss of complex III altered cytosolic and mitochondrial Ca2+ signaling and increased expression of glycolytic enzymes. Individual complexes contribute differently to β-cell function. This underscores the role of mitochondrial oxidative phosphorylation complex defects in diabetes pathogenesis.

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