Parkinson's Disease: Are Gut Microbes Involved?

Overview

Journal Brain Behav

Specialty Psychology

Date 2023 Jun 20

PMID 37340511

Authors

Abass Olawale Omotosho

Yusuf Amuda Tajudeen

Habeebullah Jayeola Oladipo

Sodiq Inaolaji Yusuff

Muritala Abdulkadir

Abdulbasit Opeyemi Muili

Oluwaseyi Muyiwa Egbewande

Rashidat Onyinoyi Yusuf

Zaccheaus Oluwaseun Faniran

Abdullateef Opeyemi Afolabi

Mona Said El-Sherbini

Affiliations

Soon will be listed here.

Abstract

Introduction: Parkinson's disease (PD) is a neurodegenerative disorder that affects more than 10 million individuals worldwide. It is characterized by motor and sensory deficits. Research studies have increasingly demonstrated a correlation between Parkinson's disease and alternations in the composition of the gut microbiota in affected patients. Also, the significant role of prebiotics and probiotics in gastrointestinal and neurological conditions is imperative to understand their relation to Parkinson's disease.

Method: To explore the scientific interaction of the gut-microbiota-brain axis and its association with Parkinson's disease, a comprehensive narrative review of the relevant literature was conducted. Articles were retrieved systematically from reputable sources, including PubMed, Science Direct, World Health Organization (WHO), and Advanced Google Scholar. Key search terms included are "Parkinson's Disease", "Gut Microbiome", "Braak's Theory", "Neurological Disorders", and "Gut-brain axis". Articles included in our review are published in English and they provide detailed information on the relationship between Parkinson's disease and gut microbiota RESULTS: This review highlights the impact of gut microbiota composition and associated factors on the progression of Parkinson's disease. Evidence-based studies highlighting the existing evidence of the relationship between Parkinson's disease and alteration in gut microbiota are discussed. Consequently, the potential mechanisms by which the gut microbiota may affect the composition of the gut microbiota were revealed, with a particular emphasis on the role of the gut-brain axis in this interplay.

Conclusion: Understanding the complex interplay between gut microbiota and Parkinson's disease is a potential implication for the development of novel therapeutics against Parkinson's disease. Following the existing relationship demonstrated by different evidence-based studies on Parkinson's disease and gut microbiota, our review concludes by providing recommendations and suggestions for future research studies with a particular emphasis on the impact of the microbiota-brain axis on Parkinson's disease.

Citing Articles

Gut Microbiome and Its Role in Parkinson's Disease.

Suresh S, Malireddi A, Abera M, Noor K, Ansar M, Boddeti S Cureus. 2024; 16(11):e73150.

PMID: 39651029 PMC: 11624045. DOI: 10.7759/cureus.73150.

The Effectiveness and Safety Analysis of Duloxetine in Treating Comorbid Depression in Parkinson's Disease: A Retrospective Study.

Wang Z, Tian J, Dai W, Zhang N, Wang J, Li Z Actas Esp Psiquiatr. 2024; 52(5):607-615.

PMID: 39403917 PMC: 11475055. DOI: 10.62641/aep.v52i5.1634.

The impact of cognitive functions, psychological disorders, and coping strategies on quality of life and disease outcomes in patients with inflammatory bowel diseases: A cross-sectional study.

Almarzouki A, Alluhaibi W, Salman B, Almuhaiyawi M, Alreemi M, Alsahafi M Medicine (Baltimore). 2024; 103(30):e38982.

PMID: 39058817 PMC: 11272307. DOI: 10.1097/MD.0000000000038982.

Gut-Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on α-Synuclein in Parkinson's Disease.

Riegelman E, Xue K, Wang J, Tang L Nutrients. 2024; 16(13).

PMID: 38999791 PMC: 11243524. DOI: 10.3390/nu16132041.

A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets.

Aziz N, Wal P, Patel A, Prajapati H Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(10):7307-7336.

PMID: 38734839 DOI: 10.1007/s00210-024-03109-4.

References

Shen T, Yue Y, He T, Huang C, Qu B, Lv W . The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis. Front Aging Neurosci. 2021; 13:636545. PMC: 7907649. DOI: 10.3389/fnagi.2021.636545. View

Braak H, de Vos R, Bohl J, Del Tredici K . Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett. 2005; 396(1):67-72. DOI: 10.1016/j.neulet.2005.11.012. View

Mertsalmi T, Aho V, Pereira P, Paulin L, Pekkonen E, Auvinen P . More than constipation - bowel symptoms in Parkinson's disease and their connection to gut microbiota. Eur J Neurol. 2017; 24(11):1375-1383. DOI: 10.1111/ene.13398. View

Warnecke T, Schafer K, Claus I, Del Tredici K, Jost W . Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management. NPJ Parkinsons Dis. 2022; 8(1):31. PMC: 8948218. DOI: 10.1038/s41531-022-00295-x. View

Cassani E, Privitera G, Pezzoli G, Pusani C, Madio C, Iorio L . Use of probiotics for the treatment of constipation in Parkinson's disease patients. Minerva Gastroenterol Dietol. 2011; 57(2):117-21. View

Dimidi E, Christodoulides S, Fragkos K, Scott S, Whelan K . The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2014; 100(4):1075-84. DOI: 10.3945/ajcn.114.089151. View

Braak H, Del Tredici K, Bratzke H, Hamm-Clement J, Sandmann-Keil D, Rub U . Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J Neurol. 2003; 249 Suppl 3:III/1-5. DOI: 10.1007/s00415-002-1301-4. View

Goldenberg M . Medical management of Parkinson's disease. P T. 2009; 33(10):590-606. PMC: 2730785. View

Tan A, Mahadeva S, Thalha A, Gibson P, Kiew C, Yeat C . Small intestinal bacterial overgrowth in Parkinson's disease. Parkinsonism Relat Disord. 2014; 20(5):535-40. DOI: 10.1016/j.parkreldis.2014.02.019. View

10.

Parashar A, Udayabanu M . Gut microbiota: Implications in Parkinson's disease. Parkinsonism Relat Disord. 2017; 38:1-7. PMC: 7108450. DOI: 10.1016/j.parkreldis.2017.02.002. View

11.

Rehman A, Sina C, Gavrilova O, Hasler R, Ott S, Baines J . Nod2 is essential for temporal development of intestinal microbial communities. Gut. 2011; 60(10):1354-62. DOI: 10.1136/gut.2010.216259. View

12.

Georgescu D, Ancusa O, Georgescu L, Ionita I, Reisz D . Nonmotor gastrointestinal disorders in older patients with Parkinson's disease: is there hope?. Clin Interv Aging. 2016; 11:1601-1608. PMC: 5113937. DOI: 10.2147/CIA.S106284. View

13.

Cryan J, ORiordan K, Sandhu K, Peterson V, Dinan T . The gut microbiome in neurological disorders. Lancet Neurol. 2019; 19(2):179-194. DOI: 10.1016/S1474-4422(19)30356-4. View

14.

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Toth M . The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014; 6(263):263ra158. PMC: 4396848. DOI: 10.1126/scitranslmed.3009759. View

15.

Unger M, Moller J, Mankel K, Schmittinger K, Eggert K, Stamelou M . Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test. Mov Disord. 2011; 26(14):2559-63. DOI: 10.1002/mds.23933. View

16.

Mohajeri M, La Fata G, Steinert R, Weber P . Relationship between the gut microbiome and brain function. Nutr Rev. 2018; 76(7):481-496. DOI: 10.1093/nutrit/nuy009. View

17.

Jaquet M, Rochat I, Moulin J, Cavin C, Bibiloni R . Impact of coffee consumption on the gut microbiota: a human volunteer study. Int J Food Microbiol. 2009; 130(2):117-21. DOI: 10.1016/j.ijfoodmicro.2009.01.011. View

18.

Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K . Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 2004; 318(1):121-34. DOI: 10.1007/s00441-004-0956-9. View

19.

Wilson B, Vatanen T, Cutfield W, OSullivan J . The Super-Donor Phenomenon in Fecal Microbiota Transplantation. Front Cell Infect Microbiol. 2019; 9:2. PMC: 6348388. DOI: 10.3389/fcimb.2019.00002. View

20.

Tu P, Chi L, Bodnar W, Zhang Z, Gao B, Bian X . Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases. Toxics. 2020; 8(1). PMC: 7151736. DOI: 10.3390/toxics8010019. View