Human Blood Barrier Models: Architectures and Applications

Overview

Journal Tissue Barriers

Specialties Anatomy & Histology
Biology
Physiology

Date 2023 Jun 20

PMID 37339009

Authors

Brittany E Watson

Julia A Miles

Melissa A Moss

Affiliations

Soon will be listed here.

Abstract

Blood barriers serve as key points of transport for essential molecules as well as lines of defense to protect against toxins. modeling of these barriers is common practice in the study of their physiology and related diseases. This review describes a common method of using an adaptable, low cost, semipermeable, suspended membrane to experimentally model three blood barriers in the human body: the blood-brain barrier (BBB), the gut-blood barrier (GBB), and the air-blood barrier (ABB). The GBB and ABB both protect from the outside environment, while the BBB protects the central nervous system from potential neurotoxic agents in the blood. These barriers share several commonalities, including the formation of tight junctions, polarized cellular monolayers, and circulatory system contact. Cell architectures used to mimic barrier anatomy as well as applications to study function, dysfunction, and response provide an overview of the versatility enabled by these cultural systems.

Citing Articles

Tissue barriers and their impact.

Turksen K Tissue Barriers. 2024; 12(4):2301799.

PMID: 38226587 PMC: 11583593. DOI: 10.1080/21688370.2024.2301799.

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