Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration

Overview

Journal Front Bioeng Biotechnol

Date 2019 Nov 30

PMID 31781555

Citations 44

Authors

Akiko Mammoto

Tadanori Mammoto

Affiliations

Soon will be listed here.

Abstract

Endothelial cells (ECs) constitute small capillary blood vessels and contribute to delivery of nutrients, oxygen and cellular components to the local tissues, as well as to removal of carbon dioxide and waste products from the tissues. Besides these fundamental functions, accumulating evidence indicates that capillary ECs form the vascular niche. In the vascular niche, ECs reciprocally crosstalk with resident cells such as epithelial cells, mesenchymal cells, and immune cells to regulate development, homeostasis, and regeneration in various organs. Capillary ECs supply paracrine factors, called angiocrine factors, to the adjacent cells in the niche and orchestrate these processes. Although the vascular niche is anatomically and functionally well-characterized in several organs such as bone marrow and neurons, the effects of endothelial signals on other resident cells and anatomy of the vascular niche in the lung have not been well-explored. This review discusses the role of alveolar capillary ECs in the vascular niche during development, homeostasis and regeneration.

Citing Articles

Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment.

Wu S, Hu Y, Sui B Cancer Manag Res. 2025; 17:249-266.

PMID: 39957904 PMC: 11829646. DOI: 10.2147/CMAR.S505549.

Multiscale computational model predicts how environmental changes and treatments affect microvascular remodeling in fibrotic disease.

Leonard-Duke J, Agro S, Csordas D, Bruce A, Eggertsen T, Tavakol T PNAS Nexus. 2024; 4(1):pgae551.

PMID: 39720203 PMC: 11667245. DOI: 10.1093/pnasnexus/pgae551.

Dynamic behavior and lineage plasticity of the pulmonary venous endothelium.

Wong J, Zhao G, Adams-Tzivelekidis S, Wen H, Chandrasekaran P, Michki S Nat Cardiovasc Res. 2024; 3(12):1584-1600.

PMID: 39653825 DOI: 10.1038/s44161-024-00573-2.

Blood flow-induced angiocrine signals promote organ growth and regeneration.

Follert P, Grosse-Segerath L, Lammert E Bioessays. 2024; 47(2):e2400207.

PMID: 39529434 PMC: 11755702. DOI: 10.1002/bies.202400207.

Inhibition of angiogenesis and regenerative lung growth in mice through adiponectin-VEGF/VEGFR2 signaling.

Hunyenyiwa T, Kyi P, Scheer M, Joshi M, Gasparri M, Mammoto T Front Cardiovasc Med. 2024; 11:1491971.

PMID: 39479393 PMC: 11521822. DOI: 10.3389/fcvm.2024.1491971.

References

Karakatsani A, Shah B, Ruiz de Almodovar C . Blood Vessels as Regulators of Neural Stem Cell Properties. Front Mol Neurosci. 2019; 12:85. PMC: 6473036. DOI: 10.3389/fnmol.2019.00085. View

Thebaud B, Ladha F, Michelakis E, Sawicka M, Thurston G, Eaton F . Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 2005; 112(16):2477-86. DOI: 10.1161/CIRCULATIONAHA.105.541524. View

Le Cras T, Markham N, Tuder R, Voelkel N, Abman S . Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. Am J Physiol Lung Cell Mol Physiol. 2002; 283(3):L555-62. DOI: 10.1152/ajplung.00408.2001. View

Mammoto T, Mammoto A . Implantation of fibrin gel on mouse lung to study lung-specific angiogenesis. J Vis Exp. 2014; (94). PMC: 4396947. DOI: 10.3791/52012. View

Ding B, Nolan D, Guo P, Babazadeh A, Cao Z, Rosenwaks Z . Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011; 147(3):539-53. PMC: 3228268. DOI: 10.1016/j.cell.2011.10.003. View

Meiners S, Eickelberg O, Konigshoff M . Hallmarks of the ageing lung. Eur Respir J. 2015; 45(3):807-27. DOI: 10.1183/09031936.00186914. View

Zhao L, Wang K, Ferrara N, Vu T . Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech Dev. 2005; 122(7-8):877-86. DOI: 10.1016/j.mod.2005.04.001. View

Apte R, Chen D, Ferrara N . VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019; 176(6):1248-1264. PMC: 6410740. DOI: 10.1016/j.cell.2019.01.021. View

Mammoto A, Muyleart M, Mammoto T . LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung. Aging (Albany NY). 2019; 11(1):89-103. PMC: 6339783. DOI: 10.18632/aging.101722. View

10.

Burri P . Fetal and postnatal development of the lung. Annu Rev Physiol. 1984; 46:617-28. DOI: 10.1146/annurev.ph.46.030184.003153. View

11.

Zeisberg E, Potenta S, Xie L, Zeisberg M, Kalluri R . Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007; 67(21):10123-8. DOI: 10.1158/0008-5472.CAN-07-3127. View

12.

Chambers E, Rounds S, Lu Q . Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury. Adv Anat Embryol Cell Biol. 2017; 228:63-86. PMC: 5930489. DOI: 10.1007/978-3-319-68483-3_4. View

13.

Tan K, Lawler J . The interaction of Thrombospondins with extracellular matrix proteins. J Cell Commun Signal. 2009; 3(3-4):177-87. PMC: 2778591. DOI: 10.1007/s12079-009-0074-2. View

14.

Dorrello N, Guenthart B, ONeill J, Kim J, Cunningham K, Chen Y . Functional vascularized lung grafts for lung bioengineering. Sci Adv. 2017; 3(8):e1700521. PMC: 5576878. DOI: 10.1126/sciadv.1700521. View

15.

Guo M, Du Y, Gokey J, Ray S, Bell S, Adam M . Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nat Commun. 2019; 10(1):37. PMC: 6318311. DOI: 10.1038/s41467-018-07770-1. View

16.

Vaccaro C, BRODY J . Ultrastructure of developing alveoli. I. The role of the interstitial fibroblast. Anat Rec. 1978; 192(4):467-79. DOI: 10.1002/ar.1091920402. View

17.

Bhatt A, Pryhuber G, Huyck H, Watkins R, Metlay L, Maniscalco W . Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001; 164(10 Pt 1):1971-80. DOI: 10.1164/ajrccm.164.10.2101140. View

18.

Dane D, Yilmaz C, Estrera A, Hsia C . Separating in vivo mechanical stimuli for postpneumonectomy compensation: physiological assessment. J Appl Physiol (1985). 2012; 114(1):99-106. PMC: 3544515. DOI: 10.1152/japplphysiol.01213.2012. View

19.

Petersen T, Calle E, Zhao L, Lee E, Gui L, Raredon M . Tissue-engineered lungs for in vivo implantation. Science. 2010; 329(5991):538-41. PMC: 3640463. DOI: 10.1126/science.1189345. View

20.

Gilpin S, Ren X, Okamoto T, Guyette J, Mou H, Rajagopal J . Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. Ann Thorac Surg. 2014; 98(5):1721-9. PMC: 4252658. DOI: 10.1016/j.athoracsur.2014.05.080. View