Mast Cells in Upper and Lower Airway Diseases: Sentinels in the Front Line

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jun 10

PMID 37298721

Authors

Giovanni Costanzo

Giulia Anna Maria Luigia Costanzo

Lorenzo Del Moro

Emanuele Nappi

Corrado Pelaia

Francesca Puggioni

Giorgio Walter Canonica

Enrico Heffler

Giovanni Paoletti

Affiliations

Soon will be listed here.

Abstract

Mast cells (MCs) are fascinating cells of the innate immune system involved not only in allergic reaction but also in tissue homeostasis, response to infection, wound healing, protection against kidney injury, the effects of pollution and, in some circumstances, cancer. Indeed, exploring their role in respiratory allergic diseases would give us, perhaps, novel therapy targets. Based on this, there is currently a great demand for therapeutic regimens to enfeeble the damaging impact of MCs in these pathological conditions. Several strategies can accomplish this at different levels in response to MC activation, including targeting individual mediators released by MCs, blockade of receptors for MC-released compounds, inhibition of MC activation, limiting mast cell growth, or inducing mast cell apoptosis. The current work focuses on and summarizes the mast cells' role in pathogenesis and as a personalized treatment target in allergic rhinitis and asthma; even these supposed treatments are still at the preclinical stage.

Citing Articles

Mast Cells in Allergic and Non-Allergic Upper Airways Diseases: Sentinel in the Watchtower.

Costanzo G, Marchetti M, Ledda A, Sambugaro G, Bullita M, Paoletti G Int J Mol Sci. 2024; 25(23).

PMID: 39684326 PMC: 11641587. DOI: 10.3390/ijms252312615.

Unraveling the Complexities of Mast Cells in Health and Disease.

Firinu D Int J Mol Sci. 2024; 25(7).

PMID: 38612600 PMC: 11012082. DOI: 10.3390/ijms25073791.

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