ANO10 is a Potential Prognostic Biomarker and Correlates with Immune Infiltration in Breast Cancer

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2023 Jun 9

PMID 37293146

Authors

Ran Ning

Shuaikang Pan

Dashu Xiao

Yan Zheng

Jinguo Zhang

Affiliations

Soon will be listed here.

Abstract

Several diseases have been linked to the dysfunction of anoctamins. Anoctamins play a wide range of physiological roles, including cell proliferation, migration, epithelial secretion, and calcium-activated chloride channel activity. However, the function of anoctamin 10 (ANO10) in breast cancer is still unclear. ANO10 was highly expressed in bone marrow, blood, skin, adipose tissue, thyroid gland and salivary gland, while ANO10 was expressed at low levels in liver and skeletal muscle. Compared to benign breast lesions, the protein level of ANO10 was lower in malignant breast tumors. However, breast cancer patients with low ANO10 expression have favorable survival outcomes. ANO10 was negatively correlated with the infiltration of memory CD4 T cells, naïve B cells, CD8 T cells, chemokines and chemokine receptors. Furthermore, the ANO10 low expression group was more sensitive to certain chemotherapy drugs, including bleomycin, doxorubicin, gemcitabine, mitomycin and etoposide. Altogether, ANO10 is a potential biomarker that can effectively predict the prognosis of breast cancer. Our findings highlight the promising prognostic value and therapeutic target of ANO10 in breast cancer.

References

Davodabadi F, Sarhadi M, Arabpour J, Sargazi S, Rahdar A, Diez-Pascual A . Breast cancer vaccines: New insights into immunomodulatory and nano-therapeutic approaches. J Control Release. 2022; 349:844-875. DOI: 10.1016/j.jconrel.2022.07.036. View

Hong R, Xu B . Breast cancer: an up-to-date review and future perspectives. Cancer Commun (Lond). 2022; 42(10):913-936. PMC: 9558690. DOI: 10.1002/cac2.12358. View

Chamova T, Florez L, Guergueltcheva V, Raycheva M, Kaneva R, Lochmuller H . ANO10 c.1150_1151del is a founder mutation causing autosomal recessive cerebellar ataxia in Roma/Gypsies. J Neurol. 2011; 259(5):906-11. DOI: 10.1007/s00415-011-6276-6. View

So J, Ohm J, Lipkowitz S, Yang L . Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options. Pharmacol Ther. 2022; 237:108253. PMC: 9378710. DOI: 10.1016/j.pharmthera.2022.108253. View

Atakpa E, Thorat M, Cuzick J, Brentnall A . Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review. Cochrane Database Syst Rev. 2021; 10:CD013091. PMC: 8545623. DOI: 10.1002/14651858.CD013091.pub2. View

Ru B, Wong C, Tong Y, Zhong J, Zhong S, Wu W . TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019; 35(20):4200-4202. DOI: 10.1093/bioinformatics/btz210. View

Kramer J, Hawley R . The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle. Nat Cell Biol. 2003; 5(3):261-3. DOI: 10.1038/ncb944. View

Zhang C, Deng Y, Zhang Y, Ba T, Niu S, Chen Y . CXCR3 Inhibition Blocks the NF-κB Signaling Pathway by Elevating Autophagy to Ameliorate Lipopolysaccharide-Induced Intestinal Dysfunction in Mice. Cells. 2023; 12(1). PMC: 9818741. DOI: 10.3390/cells12010182. View

Bethmann D, Feng Z, Fox B . Immunoprofiling as a predictor of patient's response to cancer therapy-promises and challenges. Curr Opin Immunol. 2017; 45:60-72. DOI: 10.1016/j.coi.2017.01.005. View

10.

Tian T, Zhao Y, Zheng J, Jin S, Liu Z, Wang T . Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer. Mol Ther Nucleic Acids. 2021; 26:63-80. PMC: 8411013. DOI: 10.1016/j.omtn.2021.06.017. View

11.

Zhang J, Pan S, Jian C, Hao L, Dong J, Sun Q . Immunostimulatory Properties of Chemotherapy in Breast Cancer: From Immunogenic Modulation Mechanisms to Clinical Practice. Front Immunol. 2022; 12:819405. PMC: 8766762. DOI: 10.3389/fimmu.2021.819405. View

12.

Schreiber R, Ousingsawat J, Kunzelmann K . Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling. Int J Mol Sci. 2020; 21(11). PMC: 7312528. DOI: 10.3390/ijms21114065. View

13.

Asleh K, Riaz N, Nielsen T . Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications. J Exp Clin Cancer Res. 2022; 41(1):265. PMC: 9434975. DOI: 10.1186/s13046-022-02476-1. View

14.

Heng J, Wu D, Lu S, Zhao Y . miR-106a Targets Anoctamin 1 (ANO1) to Regulate Lipopolysaccharide (LPS)-Induced Inflammatory Response in Macrophages. Med Sci Monit. 2020; 26:e922479. PMC: 7556292. DOI: 10.12659/MSM.922479. View

15.

Mizuno H, Kitada K, Nakai K, Sarai A . PrognoScan: a new database for meta-analysis of the prognostic value of genes. BMC Med Genomics. 2009; 2:18. PMC: 2689870. DOI: 10.1186/1755-8794-2-18. View

16.

Tsuji T, Cheng J, Tatematsu T, Ebata A, Kamikawa H, Fujita A . Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution. Proc Natl Acad Sci U S A. 2019; 116(27):13368-13373. PMC: 6613088. DOI: 10.1073/pnas.1822025116. View

17.

Hacking S, Yakirevich E, Wang Y . From Immunohistochemistry to New Digital Ecosystems: A State-of-the-Art Biomarker Review for Precision Breast Cancer Medicine. Cancers (Basel). 2022; 14(14). PMC: 9315712. DOI: 10.3390/cancers14143469. View

18.

Yu G, Wang L, Han Y, He Q . clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012; 16(5):284-7. PMC: 3339379. DOI: 10.1089/omi.2011.0118. View

19.

Bao X, Xie L . Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death. J Exp Clin Cancer Res. 2022; 41(1):222. PMC: 9284706. DOI: 10.1186/s13046-022-02430-1. View

20.

Renaud M, Anheim M, Kamsteeg E, Mallaret M, Mochel F, Vermeer S . Autosomal recessive cerebellar ataxia type 3 due to ANO10 mutations: delineation and genotype-phenotype correlation study. JAMA Neurol. 2014; 71(10):1305-10. DOI: 10.1001/jamaneurol.2014.193. View