CD4 T Cells Aggravate Hemorrhagic Brain Injury

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2023 Jun 7

PMID 37285421

Authors

Samuel X Shi

Yuwen Xiu

Yan Li

Meng Yuan

Kaibin Shi

Qiang Liu

Xiaoying Wang

Wei-Na Jin

Affiliations

Soon will be listed here.

Abstract

Leukocyte infiltration accelerates brain injury following intracerebral hemorrhage (ICH). Yet, the involvement of T lymphocytes in this process has not been fully elucidated. Here, we report that CD4 T cells accumulate in the perihematomal regions in the brains of patients with ICH and ICH mouse models. T cells activation in the ICH brain is concurrent with the course of perihematomal edema (PHE) development, and depletion of CD4 T cells reduced PHE volumes and improved neurological deficits in ICH mice. Single-cell transcriptomic analysis revealed that brain-infiltrating T cells exhibited enhanced proinflammatory and proapoptotic signatures. Consequently, CD4 T cells disrupt the blood-brain barrier integrity and promote PHE progression through interleukin-17 release; furthermore, the TRAIL-expressing CD4 T cells engage DR5 to trigger endothelial death. Recognition of T cell contribution to ICH-induced neural injury is instrumental for designing immunomodulatory therapies for this dreadful disease.

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