A High-performance Electrochemical Biosensor Using an Engineered Urate Oxidase

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 Jun 7

PMID 37285304

Authors

Zheng Wei

Tanja Knaus

Yuxin Liu

Ziran Zhai

Andrea F G Gargano

Gadi Rothenberg

Ning Yan

Francesco G Mutti

Affiliations

Soon will be listed here.

Abstract

We constructed a high-performance biosensor for detecting uric acid by immobilizing an engineered urate oxidase on gold nanoparticles deposited on a carbon-glass electrode. This biosensor showed a low limit-of-detection (9.16 nM), a high sensitivity (14 μA/μM), a wide range of linearity (50 nM-1 mM), and more than 28 days lifetime.

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