A Covalent Organic Polymer-TiO/TiC Heterostructure As Nonenzymatic Biosensor for Voltammetric Detection of Dopamine and Uric Acid

Heterostructures have potential to blend the advantages of each material, even exhibiting the evolutionary performance due to synergistic effects. Herein, covalent organic polymers (NUF) are integrated with a TiO/TiCT nanocomposite (TiO/TiCT) to form TiO/TiCT-NUF heterojunctions as an enlarged nonenzymatic biosensor for dopamine (DA) and uric acid (UA). Detection is performed by differential pulse voltammetry (DPV). The TiO/TiCT/NUF exhibits high sensing activity with low detection limits of 0.2 and 0.18 nM (S/N = 3) in the concentration ranges from 0.002 to 100 μM and 0.001 to 60 μM for simultaneous determination of DA and UA, respectively. In addition, the TiO/TiCT/NUF provides good selectivity and reproducibility for DA and UA detection in urine and serum samples with recoveries of 98.4 to 100.9%. The proposed heterojunctions manifest an intriguing potential as a candidate of an electrochemical sensor for sole and simultaneous detection of DA and UA.