Immediate Recruitment of Dormant Coronary Collaterals Can Provide More Than Half of Normal Resting Perfusion During Coronary Occlusion in Patients with Coronary Artery Disease

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2023 Jun 6

PMID 37280387

Authors

Brandon J Reid

Thomas Lindow

Stafford Warren

Eva Persson

Ravinay Bhindi

Michael Ringborn

Martin Ugander

Usaid Allahwala

Affiliations

Soon will be listed here.

Abstract

Background: Dormant coronary collaterals are highly prevalent and clinically beneficial in cases of coronary occlusion. However, the magnitude of myocardial perfusion provided by immediate coronary collateral recruitment during acute occlusion is unknown. We aimed to quantify collateral myocardial perfusion during balloon occlusion in patients with coronary artery disease (CAD).

Methods: Patients without angiographically visible collaterals undergoing elective percutaneous transluminal coronary angioplasty (PTCA) to a single epicardial vessel underwent two scans with 99mTc-sestamibi myocardial perfusion single-photon emission computed tomography (SPECT). All subjects underwent at least three minutes of angiographically verified complete balloon occlusion, at which time an intravenous injection of the radiotracer was administered, followed by SPECT imaging. A second radiotracer injection followed by SPECT imaging was performed 24 h after PTCA.

Results: The study included 22 patients (median [interquartile range] age 68 [54-72] years. The perfusion defect extent was 19 [11-38] % of the LV, and the collateral perfusion at rest was 64 [58-67]% of normal.

Conclusion: This is the first study to describe the magnitude of short-term changes in coronary microvascular collateral perfusion in patients with CAD. On average, despite coronary occlusion and an absence of angiographically visible collateral vessels, collaterals provided more than half of the normal perfusion.

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