Effectiveness of Smoking Cessation on the High-risk Population of Lung Cancer with Early Screening: a Systematic Review and Meta-analysis of Randomized Controlled Trials Until January 2022

Overview

Journal Arch Public Health

Publisher Biomed Central

Date 2023 Jun 2

PMID 37268972

Authors

Simin Huang

Oufeng Tang

Xutong Zheng

Hui Li

Yuxin Wu

Liu Yang

Affiliations

Soon will be listed here.

Abstract

Background: Lung cancer has always been the malignant tumor with the highest incidence rate. Smoking is the most important risk factor for lung cancer. Although potential positive effects of smoking cessation interventions on the high-risk population of lung cancer have been observed, evidence of its definitive effect remains uncertain. This study aimed to summarize the evidence related to the effects and safety of smoking cessation interventions for the high-risk population of lung cancer.

Methods: A systematic literature search was conducted through the following seven databases: PubMed, Embase, Web of Science, CENTRAL, CINAHL, PsycINFO, and Science Direct. Screening and assessment for risk of bias were conducted by two independent reviewers. Meta-analysis was performed for the 7-day-point prevalence of smoking abstinence and continuous smoking abstinence using RevMan 5.3 software.

Results: Meta-analysis results show that in the 7-day-point prevalence of smoking abstinence (by patient-reported outcome): individualized intervention was significantly higher than that of the standard care [RR = 1.46, 95%CI = (1.04,2.06), P < 0.05]. Moreover, the smoking cessation interventions were significantly elevated than that of standard care [RR = 1.58, 95%CI = (1.12, 2.23), P < 0.05] within 1-6 month follow-up time. In line with the findings in cigarette smoking, the continuous smoking abstinence of E-cigarettes (biochemical verified): E-cigarettes were significantly higher than that of the standard care [RR = 1.51, 95%CI = (1.03, 2.21), P < 0.05], and within 1-6 month follow-up time, the smoking cessation interventions were significantly greater than that of standard care [RR = 1.51, 95%CI = (1.03, 2.21), P < 0.05]. Publication bias was detected possibly.

Conclusions: The results of this systematic review show that smoking cessation intervention is effective for long-term lung cancer high-risk smokers who participate in early screening, of which E-cigarettes are the best, followed by individual smoking cessation.

Trial Registration: CRD42019147151. Registered 23 June 2022.

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References

Taylor K, Hagerman C, Luta G, Bellini P, Stanton C, Abrams D . Preliminary evaluation of a telephone-based smoking cessation intervention in the lung cancer screening setting: A randomized clinical trial. Lung Cancer. 2017; 108:242-246. PMC: 5476481. DOI: 10.1016/j.lungcan.2017.01.020. View

Cheung K, de Ruijter D, Hiligsmann M, Elfeddali I, Hoving C, Evers S . Exploring consensus on how to measure smoking cessation. A Delphi study. BMC Public Health. 2017; 17(1):890. PMC: 5696733. DOI: 10.1186/s12889-017-4902-7. View

Fucito L, Czabafy S, Hendricks P, Kotsen C, Richardson D, Toll B . Pairing smoking-cessation services with lung cancer screening: A clinical guideline from the Association for the Treatment of Tobacco Use and Dependence and the Society for Research on Nicotine and Tobacco. Cancer. 2016; 122(8):1150-9. PMC: 4828323. DOI: 10.1002/cncr.29926. View

Iaccarino J, Duran C, Slatore C, Wiener R, Kathuria H . Combining smoking cessation interventions with LDCT lung cancer screening: A systematic review. Prev Med. 2019; 121:24-32. DOI: 10.1016/j.ypmed.2019.02.016. View

de Koning H, van der Aalst C, de Jong P, Scholten E, Nackaerts K, Heuvelmans M . Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. N Engl J Med. 2020; 382(6):503-513. DOI: 10.1056/NEJMoa1911793. View

Tanner N, Kanodra N, Gebregziabher M, Payne E, Halbert C, Warren G . The Association between Smoking Abstinence and Mortality in the National Lung Screening Trial. Am J Respir Crit Care Med. 2015; 193(5):534-41. DOI: 10.1164/rccm.201507-1420OC. View

Tremblay A, Taghizadeh N, Huang J, Kasowski D, MacEachern P, Burrowes P . A Randomized Controlled Study of Integrated Smoking Cessation in a Lung Cancer Screening Program. J Thorac Oncol. 2019; 14(9):1528-1537. DOI: 10.1016/j.jtho.2019.04.024. View

Masiero M, Lucchiari C, Mazzocco K, Veronesi G, Maisonneuve P, Jemos C . E-cigarettes May Support Smokers With High Smoking-Related Risk Awareness to Stop Smoking in the Short Run: Preliminary Results by Randomized Controlled Trial. Nicotine Tob Res. 2018; 21(1):119-126. DOI: 10.1093/ntr/nty047. View

Sun D, Li H, Cao M, He S, Lei L, Peng J . Cancer burden in China: trends, risk factors and prevention. Cancer Biol Med. 2020; 17(4):879-895. PMC: 7721090. DOI: 10.20892/j.issn.2095-3941.2020.0387. View

10.

Cataldo J, Brodsky J . Lung cancer stigma, anxiety, depression and symptom severity. Oncology. 2013; 85(1):33-40. DOI: 10.1159/000350834. View

11.

Hughes J, Keely J, Niaura R, Ossip-Klein D, Richmond R, Swan G . Measures of abstinence in clinical trials: issues and recommendations. Nicotine Tob Res. 2003; 5(1):13-25. View

12.

Grable J, Lin J, Peltzer K, Schultz R, Bugbee D, Pilipenko M . Integrating Tobacco Dependence Treatment into Hospital Practice Using the Rochester Model. J Multidiscip Healthc. 2023; 16:905-911. PMC: 10082598. DOI: 10.2147/JMDH.S400615. View

13.

Buttery S, Williams P, Mweseli R, Philip K, Sadaka A, Bartlett E . Immediate smoking cessation support versus usual care in smokers attending a targeted lung health check: the QuLIT trial. BMJ Open Respir Res. 2022; 9(1). PMC: 8819808. DOI: 10.1136/bmjresp-2021-001030. View

14.

Zeliadt S, Heffner J, Sayre G, Klein D, Simons C, Williams J . Attitudes and Perceptions About Smoking Cessation in the Context of Lung Cancer Screening. JAMA Intern Med. 2015; 175(9):1530-7. DOI: 10.1001/jamainternmed.2015.3558. View

15.

Lucchiari C, Masiero M, Mazzocco K, Veronesi G, Maisonneuve P, Jemos C . Benefits of e-cigarettes in smoking reduction and in pulmonary health among chronic smokers undergoing a lung cancer screening program at 6 months. Addict Behav. 2019; 103:106222. DOI: 10.1016/j.addbeh.2019.106222. View

16.

Marshall H, Courtney D, Passmore L, McCaul E, Yang I, Bowman R . Brief Tailored Smoking Cessation Counseling in a Lung Cancer Screening Population is Feasible: A Pilot Randomized Controlled Trial. Nicotine Tob Res. 2016; 18(7):1665-9. DOI: 10.1093/ntr/ntw010. View

17.

Aberle D, Adams A, Berg C, Black W, Clapp J, Fagerstrom R . Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011; 365(5):395-409. PMC: 4356534. DOI: 10.1056/NEJMoa1102873. View

18.

Pineiro B, Simmons V, Palmer A, Correa J, Brandon T . Smoking cessation interventions within the context of Low-Dose Computed Tomography lung cancer screening: A systematic review. Lung Cancer. 2016; 98:91-98. DOI: 10.1016/j.lungcan.2016.05.028. View

19.

Caponnetto P, Campagna D, Maglia M, Benfatto F, Emma R, Caruso M . Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial. JMIR Public Health Surveill. 2023; 9:e42628. PMC: 10131829. DOI: 10.2196/42628. View

20.

Mansueto G, Carrozzino D, Sparle Christensen K, Cardellicchio S, Pezzuto A, Abrams K . Clinimetric properties of the Smoking Abstinence Expectancies Questionnaire. Addict Behav. 2021; 123:107061. DOI: 10.1016/j.addbeh.2021.107061. View