Studying Hepatic Stellate Cell Senescence

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2023 May 29

PMID 37247056

Authors

Sandra A Serna-Salas

Abel A Soto-Gamez

Zongmei Wu

Myrthe Klaver

Han Moshage

Affiliations

Soon will be listed here.

Abstract

Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis. Induction of senescence in HSCs may be a promising strategy to slow down, stop, or even reverse fibrogenesis. Senescence is a complex and heterogeneous process linked to fibrosis and cancer, but the exact mechanism and relevant markers can be cell-type dependent. Therefore, many markers of senescence have been proposed, and many methods to detect senescence have been developed. In this chapter, we review relevant methods and biomarkers to detect cellular senescence in hepatic stellate cells.

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