An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management

Overview

Journal J Pers Med

Date 2023 May 27

PMID 37240924

Authors

Farid Khallouki

Lhoussain Hajji

Somayya Saber

Toufik Bouddine

Mouad Edderkaoui

Mohammed Bourhia

Nora Mir

Adrian Lim

Adil El Midaoui

John P Giesy

Mourad A M Aboul-Soud

Sandrine Silvente-Poirot

Marc Poirot

Affiliations

Soon will be listed here.

Abstract

Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which represents 70% of all BC subtypes. This review assesses the current knowledge on the molecular pharmacology of tamoxifen in terms of its anticancer and chemo-preventive actions. Due to the importance of vitamin E compounds, which are widely taken as a supplementary dietary component, the review focuses only on the potential importance of vitamin E in BC chemo-prevention. The chemo-preventive and onco-protective effects of tamoxifen combined with the potential effects of vitamin E can alter the anticancer actions of tamoxifen. Therefore, methods involving an individually designed, nutritional intervention for patients with BC warrant further consideration. These data are of great importance for tamoxifen chemo-prevention strategies in future epidemiological studies.

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References

Adzersen K, Jess P, Freivogel K, Gerhard I, Bastert G . Raw and cooked vegetables, fruits, selected micronutrients, and breast cancer risk: a case-control study in Germany. Nutr Cancer. 2003; 46(2):131-7. DOI: 10.1207/S15327914NC4602_05. View

Musa M, Khan M, Cooperwood J . Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs). Curr Med Chem. 2007; 14(11):1249-61. DOI: 10.2174/092986707780598023. View

Sailo B, Banik K, Padmavathi G, Javadi M, Bordoloi D, Kunnumakkara A . Tocotrienols: The promising analogues of vitamin E for cancer therapeutics. Pharmacol Res. 2018; 130:259-272. DOI: 10.1016/j.phrs.2018.02.017. View

Kim Y, Lee S, Jung J, Kwon Y, Lee G, Shin D . Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus. Chin J Cancer Res. 2014; 26(3):341-4. PMC: 4076723. DOI: 10.3978/j.issn.1000-9604.2014.05.01. View

Arpino G, Wiechmann L, Osborne C, Schiff R . Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocr Rev. 2008; 29(2):217-33. PMC: 2528847. DOI: 10.1210/er.2006-0045. View

Cui Y, Shikany J, Liu S, Shagufta Y, Rohan T . Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study. Am J Clin Nutr. 2008; 87(4):1009-18. PMC: 2753414. DOI: 10.1093/ajcn/87.4.1009. View

Iqbal J, Minhajuddin M, Beg Z . Suppression of 7,12-dimethylbenz[alpha]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil. Eur J Cancer Prev. 2003; 12(6):447-53. DOI: 10.1097/00008469-200312000-00002. View

Miller T, Ghoshal K, Ramaswamy B, Roy S, Datta J, Shapiro C . MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J Biol Chem. 2008; 283(44):29897-903. PMC: 2573063. DOI: 10.1074/jbc.M804612200. View

Johnson M, Zuo H, Lee K, Trebley J, Rae J, Weatherman R . Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res Treat. 2004; 85(2):151-9. DOI: 10.1023/B:BREA.0000025406.31193.e8. View

10.

Liu C, Yang T . Sequential changes in serum triglyceride levels during adjuvant tamoxifen therapy in breast cancer patients and the effect of dose reduction. Breast Cancer Res Treat. 2003; 79(1):11-6. DOI: 10.1023/a:1023348021773. View

11.

Tiwary R, Yu W, Li J, Park S, Sanders B, Kline K . Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS One. 2010; 5(7):e11865. PMC: 2912340. DOI: 10.1371/journal.pone.0011865. View

12.

Malafa M, Fokum F, Smith L, Louis A . Inhibition of angiogenesis and promotion of melanoma dormancy by vitamin E succinate. Ann Surg Oncol. 2002; 9(10):1023-32. DOI: 10.1007/BF02574523. View

13.

Ozdemir B, Pentcheva-Hoang T, Carstens J, Zheng X, Wu C, Simpson T . Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014; 25(6):719-34. PMC: 4180632. DOI: 10.1016/j.ccr.2014.04.005. View

14.

Kuo S, Yang S, You S, Lien H, Lin C, Lin P . Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer. Oncotarget. 2017; 8(13):20925-20938. PMC: 5400556. DOI: 10.18632/oncotarget.14995. View

15.

Schmolz L, Birringer M, Lorkowski S, Wallert M . Complexity of vitamin E metabolism. World J Biol Chem. 2016; 7(1):14-43. PMC: 4768118. DOI: 10.4331/wjbc.v7.i1.14. View

16.

de Medina P, Silvente-Poirot S, Poirot M . Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Autophagy. 2009; 5(7):1066-7. DOI: 10.4161/auto.5.7.9820. View

17.

Bjelakovic G, Nikolova D, Gluud L, Simonetti R, Gluud C . Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008; (2):CD007176. DOI: 10.1002/14651858.CD007176. View

18.

AlZaabi A, AlAmri H, ALAjmi G, Allawati M, Muhanna F, Alabri R . Endometrial Surveillance in Tamoxifen and Letrozole Treated Breast Cancer Patients. Cureus. 2022; 13(11):e20030. PMC: 8716161. DOI: 10.7759/cureus.20030. View

19.

McGlynn L, Kirkegaard T, Edwards J, Tovey S, Cameron D, Twelves C . Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients. Clin Cancer Res. 2009; 15(4):1487-95. DOI: 10.1158/1078-0432.CCR-07-4967. View

20.

Lee H, Ju J, Paul S, So J, DeCastro A, Smolarek A . Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma. Clin Cancer Res. 2009; 15(12):4242-9. PMC: 2753525. DOI: 10.1158/1078-0432.CCR-08-3028. View