Ethnobotanical Uses and Phytochemical, Biological, and Toxicological Profiles of L.: A Review

Overview

Journal Curr Res Toxicol

Specialty Biology

Date 2023 May 25

PMID 37228329

Authors

Tawhida Islam

Iffat Ara

Tariqul Islam

Pankaj Kumar Sah

Ray Silva de Almeida

Edinardo Fagner Ferreira Matias

Cicero Lucas Gomes Ramalho

Henrique Douglas M Coutinho

Muhammad Torequl Islam

Affiliations

Soon will be listed here.

Abstract

Datura metel L., a recognized poisonous plant in the Solanaceae family, is widely distributed in the world. Traditionally, D. metel is used in many diseases, including neurological and heart diseases; fever; catarrh; pain; diarrhea; skin diseases; chronic bronchitis; asthma; digestive disorders; and so on. It possesses many important phytochemicals that can be used to treat various types of diseases. This review aims at summarizing the traditional uses, phytochemical, biological, and toxicological profiles of D. metel based on the database reports. For this, an up-to-date (till March 20, 2023) search was made in the databases: PubMed, Google Scholar, Science Direct, Scopus, and MedLine, with relevant keywords for the published evidence. Findings suggest that the plant has many traditional uses, such as a cure for madness, epilepsy, psoriasis, heart diseases, diarrhea, mad dog bites, indigestion, etc. It possesses various important phytochemicals, including withanolides, daturaolone, datumetine, daturglycosides, ophiobolin A, baimantuoluoline A, and many others. D. metel has many important biological activities, including antioxidant, anti-inflammatory, anti-microbial, insecticidal, anti-cancer, anti-diabetic, analgesic, anti-pyretic, neurological, contraceptive, and wound healing capacity. In conclusion, the toxic plant, D. metel, can be considered a potential source of phyto-therapeutic lead compounds.

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