Antioxidant Activity of Aqueous Extract of Leaves and Seeds of (Solanaceae) in Frog's Heart Failure Model

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2022 May 23

PMID 35600941

Authors

H Mbida

D E Tsala

S Aboubakar

S Habtemariam

J J Edmond

E F Bakwo

J Z Minkande

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this work was to evaluate the antioxidant potential of .

Materials And Methods: Heart failure was induced in the frog's heart by continuous perfusion of hydrogen peroxide. Survival time and some heart tissue parameters of oxidative stress were recorded in the presence of aqueous extracts of the leaves and seeds of . Ascorbic acid was used as a reference drug.

Results: HO-enriched Ringer's solution inhibited the negative inotropic and chronotropic effects of acetylcholine, indicating the desensibilization of muscarinic receptors due to HO-induced oxidative stress. These hearts had a relatively short survival time (14 minutes). In the presence of the aqueous extract of the leaves and seeds of (1.5 and 2.5 mg/mL), the time necessary to cause the cardiac arrest was extended to 35 and 37 minutes, respectively, versus 29 minutes for ascorbic acid and 14 minutes for HO. Furthermore, antioxidant parameters (MDA, SOD, and CAT) were significantly improved in plant extract-treated hearts, compared to peroxidized hearts.

Conclusion: Aqueous extract of the leaves and seeds of . can extend heart survival time through antioxidant mechanisms.

Citing Articles

Anti-Diabetic Effects of the 80% Methanolic Extract of Datura Stramonium Linn (Solanaceae) Leaves in Streptozotocin- Induced Diabetic Mice.

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Ethnobotanical uses and phytochemical, biological, and toxicological profiles of L.: A review.

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