BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Overview

Journal Cancer Res

Specialty Oncology

Date 2023 May 25

PMID 37227919

Authors

Xiaodong Shu

Jianjie Li

Un In Chan

Sek Man Su

Changxiang Shi

Xin Zhang

Tingting An

Jun Xu

Lihua Mo

Jianlin Liu

Yuqing Wang

Xiaoling Li

Min Deng

Josh Haipeng Lei

Chunfei Wang

Hao Tian

Sun Heng

Joong Sup Shim

Xuanjun Zhang

Yunlu Dai

Zhicheng Yao

Xiaying Kuang

Ying Lin

Chu-Xia Deng

Xiaoling Xu

Affiliations

Soon will be listed here.

Abstract

Significance: BRCA1 deficiency generates an acidic microenvironment to promote cancer metastasis and immunotherapy resistance that can be reversed using a sialyltransferase inhibitor.

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