The Essential Role of N6-methyladenosine RNA Methylation in Complex Eye Diseases

Overview

Journal Genes Dis

Date 2023 May 24

PMID 37223523

Authors

Xiaohua Li

Binyun Ma

Wenfang Zhang

Zongming Song

Xiaodan Zhang

Mengyu Liao

Xue Li

Xueru Zhao

Mei Du

Jinguo Yu

Shikun He

Hua Yan

Affiliations

Soon will be listed here.

Abstract

There are many complex eye diseases which are the leading causes of blindness, however, the pathogenesis of the complex eye diseases is not fully understood, especially the underlying molecular mechanisms of N6-methyladenosine (m6A) RNA methylation in the eye diseases have not been extensive clarified. Our review summarizes the latest advances in the studies of m6A modification in the pathogenesis of the complex eye diseases, including cornea disease, cataract, diabetic retinopathy, age-related macular degeneration, proliferative vitreoretinopathy, Graves' disease, uveal melanoma, retinoblastoma, and traumatic optic neuropathy. We further discuss the possibility of developing m6A modification signatures as biomarkers for the diagnosis of the eye diseases, as well as potential therapeutic approaches.

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