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LncRNA MEG3 Promotes Chemosensitivity of Osteosarcoma by Regulating Antitumor Immunity Via MiR-21-5p/p53 Pathway and Autophagy

Overview
Journal Genes Dis
Date 2023 May 24
PMID 37223512
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Abstract

This study aimed to investigate the role of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) in chemosensitivity of osteosarcoma (OS), and to reveal the possible underlying mechanisms. In this study, we found that the expression of lncRNA MEG3 was significantly lower in OS tissues and cell lines. Furthermore, lncRNA MEG3 overexpression enhanced chemosensitivity of OS by inhibiting cell proliferation, migration, autophagy, and promoting antitumor immunity. LncRNA MEG3 functioned as miR-21-5 sponge to regulate p53 expression in OS. Mechanically, lncRNA MEG3 promoted OS chemosensitivity by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy. Collectively, this study provided the evidence that lncRNA MEG3 might be a promising therapeutic target for OS chemoresistance.

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References
1.
Waniczek D, Lorenc Z, Snietura M, Wesecki M, Kopec A, Muc-Wierzgon M . Tumor-Associated Macrophages and Regulatory T Cells Infiltration and the Clinical Outcome in Colorectal Cancer. Arch Immunol Ther Exp (Warsz). 2017; 65(5):445-454. PMC: 5602054. DOI: 10.1007/s00005-017-0463-9. View

2.
Mowers E, Sharifi M, Macleod K . Autophagy in cancer metastasis. Oncogene. 2016; 36(12):1619-1630. PMC: 5337449. DOI: 10.1038/onc.2016.333. View

3.
Ma B, Gao Z, Lou J, Zhang H, Yuan Z, Wu Q . Long non‑coding RNA MEG3 contributes to cisplatin‑induced apoptosis via inhibition of autophagy in human glioma cells. Mol Med Rep. 2017; 16(3):2946-2952. DOI: 10.3892/mmr.2017.6897. View

4.
Huang X, Hu H, Zhang W, Shao Z . Prognostic value of prognostic nutritional index and systemic immune-inflammation index in patients with osteosarcoma. J Cell Physiol. 2019; 234(10):18408-18414. DOI: 10.1002/jcp.28476. View

5.
Luetke A, Meyers P, Lewis I, Juergens H . Osteosarcoma treatment - where do we stand? A state of the art review. Cancer Treat Rev. 2013; 40(4):523-32. DOI: 10.1016/j.ctrv.2013.11.006. View