Hypertensive Disorders of Pregnancy and Subsequent Risk of Alzheimer's Disease and Other Dementias

Overview

Journal Alzheimers Dement (Amst)

Date 2023 May 24

PMID 37223334

Authors

Karen C Schliep

C Elizabeth Shaaban

Huong Meeks

Alison Fraser

Ken R Smith

Jennifer J Majersik

Norman L Foster

Jean Wactawski-Wende

Truls Ostbye

Joann Tschanz

James F Padbury

Surrendra Sharma

Yue Zhang

Julio C Facelli

C Samir Abdelrahman

Lauren Theilen

Michael W Varner

Affiliations

Soon will be listed here.

Abstract

Introduction: Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored.

Methods: Using the Utah Population Database, we performed an 80-year retrospective cohort study of 59,668 parous women.

Results: Women with, versus without, HDP, had a 1.37 higher risk of all-cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal age at index birth, birth year, and parity. HDP was associated with a 1.64 higher risk of vascular dementia (95% CI: 1.19, 2.26) and 1.49 higher risk of other dementia (95% CI: 1.34, 1.65) but not Alzheimer's disease dementia (adjusted hazard ratio = 1.04; 95% CI: 0.87, 1.24). Gestational hypertension and preeclampsia/eclampsia showed similar increased dementia risk. Nine mid-life cardiometabolic and mental health conditions explained 61% of HDP's effect on subsequent dementia risk.

Discussion: Improved HDP and mid-life care could reduce the risk of dementia.

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