Dynapenic Abdominal Obesity and Susceptibility to Fall: a Prospective Analysis of the Osteoarthritis Initiative

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2023 May 22

PMID 37215209

Authors

Nicola Veronese

Ai Koyanagi

Pinar Soysal

Francesco Bolzetta

Ligia J Dominguez

Mario Barbagallo

Shaun Sabico

Nasser M Al-Daghri

Lee Smith

Affiliations

Soon will be listed here.

Abstract

Background: The prediction of the risk of falling remains a challenge in geriatric medicine and the identification of new potential reversible risk factors is a public health priority. In this study, we aim to investigate the association between DAO (dynapenic abdominal obesity) and incident falls in a large sample of people with knee OA (osteoarthritis) or at high risk for this condition, over 8 years of follow-up.

Methods: DAO was defined using a waist circumference more than 102 cm in men and 88 cm in women and a concomitant presence of dynapenia, defined as a time over 15 s in the five times chair stands time. Falls, during follow-up, were recorded using self-reported information in the previous year. A logistic binary regression analysis was run, adjusted for potential confounders at the baseline, reporting the data as odds ratios (ORs) with their 95% confidence intervals (CIs).

Results: Overall, 3,844 subjects were included, majority of whom had abdominal obesity. Across the 8 years of follow-up, 2,695 participants fell vs. 1,149 not reporting any fall. Taking those without DAO as reference, the presence of only dynapenia was not associated with risk of falls (OR = 1.18;95%CI: 0.73-1.91; = 0.50), whilst the presence of abdominal obesity (OR = 1.30; 95%CI: 1.09-1.56; = 0.004) and DAO (OR = 1.31; 95%CI:1.01-1.73; = 0.04) were significantly associated with a higher risk of incident falls.

Conclusion: DAO significantly increased risk of falls as well as the presence of abdominal obesity.

Citing Articles

Dynapenic abdominal obesity and incident multimorbidity: findings from the English longitudinal study on ageing.

Veronese N, Koyanagi A, Soysal P, Sapienza V, Ragusa F, Bolzetta F Aging Clin Exp Res. 2023; 35(8):1671-1678.

PMID: 37273091 PMC: 10363082. DOI: 10.1007/s40520-023-02455-2.

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