Gene Polymorphism is Associated with Downregulation of Expression, Suppressor of Cytokine Signaling-1 Overexpression, and Low Probability of Metastatic Tumor at the Time of Breast Cancer Diagnosis

Background: is a key player in inflammatory reactions, carcinogenesis, and tumor development. In this study, polymorphism of and its gene and suppressor of cytokine signaling-1 (SOCS-1) expression were investigated in relation to cancer susceptibility and development in breast cancer (BC) patients.

Materials And Methods: Polymorphism of was evaluated between a population of 174 patients with BC and 129 controls using restriction fragment length polymorphism and the expression of and SOCS-1 were examined in peripheral blood mononuclear cells (PBMCs) by real-time polymerase chain reaction.

Results: TT genotype of was associated with higher level of in PBMCs of BC patients relative to AT and AA genotypes (21.76 ± 4.4, 4.046 ± 1.35, 2.56 ± 0.81, respectively; < 0.001) and increased lymph node metastasis ( = 0.292, = 0.001), not BC susceptibility ( = 0.402 and = 0.535; respectively). TT genotype of was associated with less gene expression of SOCS-1 in PBMCs of BC patients compared to AT and AA genotypes (1.173 ± 0.57, 0.92 ± 0.827, 5.512 ± 0.92, respectively; = 0.003).

Conclusion: This study demonstrated for the first time the association between the T allele of the polymorphism in the gene and higher expression of , lower expression of SOCS-1, and swift latent progression in newly diagnosed BC patients. Thus, may play a critical role in BC pathogenesis.