Neutrophils Extracellular Traps and Ferroptosis in Diabetic Wounds

Overview

Journal Int Wound J

Specialties Emergency Medicine
Orthopedics

Date 2023 May 18

PMID 37199077

Authors

Yumeng Huang

Youjun Ding

Beizhi Wang

Qian Ji

Chen Peng

Qian Tan

Affiliations

Soon will be listed here.

Abstract

Wound healing is an extremely complex process involving multiple levels of cells and tissues. It is mainly completed through four stages: haemostasis, inflammation, proliferation, and remodelling. When any one of these stages is impaired, it may lead to delayed healing or even transformation into chronic refractory wounds. Diabetes is a kind of common metabolic disease that affects approximately 500 million people worldwide, 25% of whom develop skin ulcers that break down repeatedly and are difficult to heal, making it a growing public health problem. Neutrophils extracellular traps and ferroptosis are new types of programmed cell death identified in recent years and have been found to interact with diabetic wounds. In this paper, the normal wound healing and interfering factors of the diabetic refractory wound were outlined. The mechanism of two kinds of programmed cell death was also described, and the interaction mechanism between different types of programmed cell death and diabetic refractory wounds was discussed.

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