Facile Synthesis of Chiral Phenylselenides As Novel Antioxidants and Cytotoxic Agents

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 May 17

PMID 37197685

Authors

Anna Laskowska

Agata J Pacula-Miszewska

Magdalena Obieziurska-Fabisiak

Aneta Jastrzebska

Katarzyna Gach-Janczak

Anna Janecka

Jacek Scianowski

Affiliations

Soon will be listed here.

Abstract

Organoselenium compounds are well-known for their unique biological properties, including antioxidant, anticancer and anti-inflammatory. They result from the presence of a particular Se-moiety enclosed in a structure that provides physicochemical features necessary for effective drug-target interactions. Looking for a proper drug design that considers the influence of each structural element has to be conducted. In this paper, we have synthesized a series of chiral phenylselenides, possessing an additional -substituted amide moiety, and evaluated their antioxidant and anticancer potential. The presented derivatives, as a group of enantiomeric and diastereomeric pairs, enabled a thorough investigation of the 3D structure-activity dependence in correlation with the presence of the phenylselanyl group as the potential pharmacophore. The -indanyl derivatives possessing a - and -2-hydroxy group were selected as the most promising antioxidants and anticancer agents.

Citing Articles

Synthesis of a New Class of -Carbonyl Selenides Functionalized with Ester Groups with Antioxidant and Anticancer Properties-Part II.

Laskowska A, Pacula-Miszewska A, Obieziurska-Fabisiak M, Jastrzebska A, Dlugosz-Pokorska A, Gach-Janczak K Molecules. 2024; 29(12).

PMID: 38930931 PMC: 11206731. DOI: 10.3390/molecules29122866.

Synthesis of New Chiral -Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluation-Part I.

Laskowska A, Pacula-Miszewska A, Obieziurska-Fabisiak M, Jastrzebska A, Dlugosz-Pokorska A, Gach-Janczak K Materials (Basel). 2024; 17(4).

PMID: 38399148 PMC: 10890689. DOI: 10.3390/ma17040899.

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